De Los Ríos-Pérez Ana, García Alberto Federico, Gomez Paula, Arias Juan José, Fandiño-Losada Andrés
Pediatric Emergency Medicine, Fundación Valle del Lili Teaching Hospital, Cali, Colombia.
Faculty of Health Sciences, Universidad Icesi, Cali, Colombia.
Front Pediatr. 2024 Dec 12;12:1481467. doi: 10.3389/fped.2024.1481467. eCollection 2024.
Pediatric trauma is a major global health concern, accounting for a substantial proportion of deaths and disease burden from age 5 onwards. Effective triage and management are essential in pediatric trauma care, and prediction models such as the Trauma Injury Severity Score (TRISS) play a crucial role in estimating survival probability and guiding quality improvement. However, TRISS does not account for age-specific factors in pediatric populations, limiting its applicability to younger patients. This study aimed to modify TRISS to account for age for children (Peds-TRISS) and to evaluate its performance relative to the original TRISS. We also assessed survival outcomes to explore the model's potential utility across various clinical settings. These efforts align with quality improvement initiatives to reduce preventable mortality and supporting sustainable development goals.
This retrospective cohort study included patients under 18 years of age who were treated at a hospital in Colombia between 2011 and 2019. New coefficients for TRISS covariates were calculated using logistic regression, with age treated as a continuous variable. Model performance was evaluated based on discrimination (C statistic) and calibration, comparing Peds-TRISS with the original TRISS. Internal validation was conducted using bootstrap resampling. Survival outcomes were assessed using the M and Z statistics, which are commonly used for international trauma outcome comparisons.
The study included 1,013 pediatric patients with a median age of 12 years (IQR 5-15), of whom 73% were male. The leading causes of injury were traffic accidents (31.1%), falls (28.8%), and assaults (28.7%). The overall mortality rate was 5.7%. The Peds-TRISS model demonstrated good calibration (HL = 9.7, = 0.3) and discrimination (C statistic = 0.98, 95% CI 0.97-0.99), with no statistically significant difference in the ROC curve comparison with the original TRISS. Internal validation demonstrated strong performance of Peds-TRISS. The M and statistics were 0.93 and 0, respectively, indicating no significant differences between expected and observed survival rates.
Most fatalities occurred among adolescents and were due to intentional injuries. The Peds-TRISS model showed a partial improvement in performance compared to the original TRISS, with superior results in terms of calibration, although not in discrimination. These findings highlight the potential of model customization for specific populations. Prospective, multicenter studies are recommended to further validate the model's utility across diverse settings.
儿童创伤是全球主要的健康问题,从5岁起就占死亡和疾病负担的很大比例。有效的分诊和管理在儿童创伤护理中至关重要,诸如创伤损伤严重程度评分(TRISS)等预测模型在估计生存概率和指导质量改进方面发挥着关键作用。然而,TRISS未考虑儿童群体中特定年龄因素,限制了其在年轻患者中的适用性。本研究旨在修改TRISS以考虑儿童年龄因素(儿童TRISS),并评估其相对于原始TRISS的性能。我们还评估了生存结局,以探索该模型在各种临床环境中的潜在效用。这些努力与减少可预防死亡的质量改进举措以及支持可持续发展目标相一致。
这项回顾性队列研究纳入了2011年至2019年在哥伦比亚一家医院接受治疗的18岁以下患者。使用逻辑回归计算TRISS协变量的新系数,将年龄作为连续变量处理。基于区分度(C统计量)和校准评估模型性能,将儿童TRISS与原始TRISS进行比较。使用自抽样法进行内部验证。使用常用于国际创伤结局比较的M和Z统计量评估生存结局。
该研究纳入了1013名儿童患者,中位年龄为12岁(四分位间距5 - 15岁),其中73%为男性。主要损伤原因是交通事故(31.1%)、跌倒(28.8%)和袭击(28.7%)。总体死亡率为5.7%。儿童TRISS模型显示出良好的校准(HL = 9.7, = 0.3)和区分度(C统计量 = 0.98,95%置信区间0.97 - 0.99),与原始TRISS的ROC曲线比较无统计学显著差异。内部验证表明儿童TRISS性能良好。M和统计量分别为0.93和0,表明预期生存率与观察到的生存率之间无显著差异。
大多数死亡发生在青少年中,且是由于故意伤害。与原始TRISS相比,儿童TRISS模型在性能上有部分改进,在校准方面有更好的结果,尽管在区分度方面没有。这些发现凸显了针对特定人群定制模型的潜力。建议进行前瞻性、多中心研究以进一步验证该模型在不同环境中的效用。