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通过将咖啡酸掺入亲水性凝胶中来潜在释放其生物活性。

Potential Unlocking of Biological Activity of Caffeic Acid by Incorporation into Hydrophilic Gels.

作者信息

Jokubaite Monika, Ramanauskiene Kristina

机构信息

Department of Drug Chemistry, Faculty of Pharmacy, Lithuanian University of Health Sciences, Sukileliai Avenue 13, LT-50162 Kaunas, Lithuania.

Department of Clinical Pharmacy, Faculty of Pharmacy, Lithuanian University of Health Sciences, Sukileliai Avenue 13, LT-50162 Kaunas, Lithuania.

出版信息

Gels. 2024 Dec 4;10(12):794. doi: 10.3390/gels10120794.

DOI:10.3390/gels10120794
PMID:39727552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11675749/
Abstract

Caffeic acid, a phenolic compound with antioxidant and antimicrobial properties, shows promise in the dermatological field. The research aimed to incorporate caffeic acid into hydrophilic gels based on poloxamer 407, carbomer 980, and their mixture in order to enhance its biological activity. Different gel formulations were prepared using different concentrations of these polymers to optimize caffeic acid release characteristics. The results showed that increasing the concentration of polymeric materials increased the viscosity and slowed down the release of caffeic acid. The antioxidant and antimicrobial activities of the gels were assessed. The results confirmed the potential of hydrophilic gels as delivery systems for caffeic acid, with formulations showing antimicrobial activity against Gram-positive bacteria and antifungal activity against fungus. This study provides a perception of the development of new semi-solid caffeic acid-based formulations for therapeutic and cosmetic applications.

摘要

咖啡酸是一种具有抗氧化和抗菌特性的酚类化合物，在皮肤病学领域显示出应用前景。该研究旨在将咖啡酸掺入基于泊洛沙姆407、卡波姆980及其混合物的亲水性凝胶中，以增强其生物活性。使用这些聚合物的不同浓度制备了不同的凝胶配方，以优化咖啡酸的释放特性。结果表明，增加聚合物材料的浓度会增加粘度并减缓咖啡酸的释放。对凝胶的抗氧化和抗菌活性进行了评估。结果证实了亲水性凝胶作为咖啡酸递送系统的潜力，其配方对革兰氏阳性菌显示出抗菌活性，对真菌显示出抗真菌活性。本研究为开发用于治疗和美容应用的新型半固体咖啡酸基制剂提供了思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d9/11675749/695c8704c8c5/gels-10-00794-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d9/11675749/d5e213cf333b/gels-10-00794-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d9/11675749/118df11d4c16/gels-10-00794-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d9/11675749/e1ba9d70d62c/gels-10-00794-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d9/11675749/695c8704c8c5/gels-10-00794-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d9/11675749/be688f0b3c92/gels-10-00794-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d9/11675749/2e494e2a32bb/gels-10-00794-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d9/11675749/8ddced181931/gels-10-00794-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d9/11675749/12805c06adfb/gels-10-00794-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d9/11675749/d5e213cf333b/gels-10-00794-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d9/11675749/118df11d4c16/gels-10-00794-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d9/11675749/e1ba9d70d62c/gels-10-00794-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d9/11675749/695c8704c8c5/gels-10-00794-g008.jpg

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本文引用的文献

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3
Gel Formulations for Topical Treatment of Skin Cancer: A Review.用于皮肤癌局部治疗的凝胶制剂：综述
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4
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