Czerwińska-Ledwig Olga, Żychowska Małgorzata, Jurczyszyn Artur, Kryst Joanna, Dzidek Adrianna, Zuziak Roxana, Jurczyszyn Anna, Piotrowska Anna
Institute for Basic Sciences, Faculty of Physiotherapy, University of Physical Education, 31-571 Krakow, Poland.
Faculty of Health Sciences and Physical Culture, Biological Fundation of Physical Culture, Kazimierz Wielki University in Bydgoszcz, 85-064 Bydgoszcz, Poland.
Curr Oncol. 2024 Dec 14;31(12):7960-7970. doi: 10.3390/curroncol31120587.
Multiple myeloma, a malignancy of plasma cells, often involves the disruption of vitamin D metabolism. Vitamin D, acting through its receptor (VDR), affects transcription factors like FOXO and sirtuins, which regulate cellular processes. The impact of physical activity on these markers in multiple myeloma patients is unclear. Therefore, the objective of this study was to evaluate the effects of a 6-week training program on these parameters.
The study was completed by 30 patients, including 16 in the Nordic walking training group (TG) and 14 in the control group (non-exercising, CG). All participants underwent a thorough medical interview before starting the project. Venous blood samples were collected from all participants four times-at baseline, after 3 weeks, after 6 weeks, and after 9 weeks (follow-up). The serum concentrations of sirtuin 1, sirtuin 3, Foxo3a, vitamin D receptor (VDR), 25(OH)D3, and 1,25(OH)2D were determined. Body composition, physical fitness, and physical activity level were assessed at baseline and after 6 weeks.
No statistically significant changes were observed in the serum levels of sirtuins, the FOXO3a protein, and 1,25(OH)2D. A statistically significant difference was observed in the levels of VDR for both time and group factors, but this was not confirmed in the post hoc test. Vitamin 25(OH)D3 level increased significantly in the study group with time.
The applied 6-week Nordic walking training cycle positively affected the level of vitamin 25(OH)D3 but did not influence the rest of the biochemical parameters studied. The obtained results also indicate that the applied intervention is safe for patients and does not interfere with body composition.
多发性骨髓瘤是一种浆细胞恶性肿瘤，常涉及维生素D代谢紊乱。维生素D通过其受体（VDR）发挥作用，影响诸如FOXO和沉默调节蛋白等转录因子，这些转录因子调控细胞过程。体育活动对多发性骨髓瘤患者这些标志物的影响尚不清楚。因此，本研究的目的是评估为期6周的训练计划对这些参数的影响。
该研究由30名患者完成，其中16名在北欧式健走训练组（TG），14名在对照组（不运动，CG）。所有参与者在项目开始前均接受了全面的医学访谈。在基线、3周后、6周后和9周后（随访）从所有参与者身上采集四次静脉血样。测定血清中沉默调节蛋白1、沉默调节蛋白3、Foxo3a、维生素D受体（VDR）、25（OH）D3和1,25（OH）2D的浓度。在基线和6周后评估身体成分、体能和身体活动水平。
沉默调节蛋白、FOXO3a蛋白和1,25（OH）2D的血清水平未观察到统计学上的显著变化。VDR水平在时间和组因素上均观察到统计学上的显著差异，但在事后检验中未得到证实。研究组中维生素25（OH）D3水平随时间显著升高。
应用的为期6周的北欧式健走训练周期对维生素25（OH）D3水平有积极影响，但对其他所研究的生化参数没有影响。所获得的结果还表明，所应用的干预措施对患者是安全的，并且不影响身体成分。
