Fogel B S, Satel S L
J Clin Psychiatry. 1985 Mar;46(3):95-7.
A dexamethasone suppression test (DST) was administered to 89 general hospital inpatients as part of an evaluation of depressed mood. Among the 55 patients with major depressive disorder (MDD), age was positively correlated with postdexamethasone cortisol (r=.317, p=.002 at 4 p.m.). The patients without MDD did not show this effect. Postdexamethasone cortisol concentrations of 15 micrograms/dl or greater were seen in 31% of 32 patients over 60 with MDD; they did not occur in 23 patients under 60 with MDD. The results suggest a clinically relevant effect of age on the DST in patients with MDD.
作为对抑郁情绪评估的一部分，对89名综合医院住院患者进行了地塞米松抑制试验（DST）。在55名重度抑郁症（MDD）患者中，年龄与地塞米松给药后皮质醇水平呈正相关（下午4点时，r = 0.317，p = 0.002）。无MDD的患者未显示出这种效应。在32名60岁以上的MDD患者中，31%的患者地塞米松给药后皮质醇浓度达到或超过15微克/分升；而在23名60岁以下的MDD患者中未出现这种情况。结果表明，年龄对MDD患者的DST有临床相关影响。
