2018 - 2020年中国山东省猪圆环病毒2型的流行情况及遗传特征
The Prevalence and Genetic Characteristics of Porcine Circovirus Type 2 in Shandong Province, China, 2018-2020.
作者信息
Zhao Yuzhong, Cui Xinyu, Sang Haotian, Wen Shaodong, Han Lebin, Yang Pingping, Xiao Yihong, Hou Yanmeng
机构信息
College of Animal Science and Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai'an 271018, China.
Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Tai'an 271018, China.
出版信息
Curr Issues Mol Biol. 2024 Nov 26;46(12):13542-13553. doi: 10.3390/cimb46120809.
Porcine circovirus type 2 (PCV2) is an important swine pathogen that has caused considerable economic losses in the global swine industry. During our surveillance of pigs in Shandong, China, from 2018 to 2020, we found that the PCV2 infection rate was 7.89% (86/1090). In addition, we found frequent mixed infections of PCV2 with porcine reproductive and respiratory syndrome virus (PRRSV), classical swine fever virus (CSFV), and porcine herpesvirus (PRV). Thirteen positive clinical samples were selected to amplify the complete genome of PCV2, and were sequenced. Among the 13, we detected two genotypes: PCV2b (1/13) and PCV2d (12/13). This suggests that PCV2d is the dominant genotype circulating in Shandong Province. Additionally, we found three positively selected sites in the ORF2 region, located on the previously reported antigenic epitopes. This investigation will contribute to understanding of the molecular epidemiology and genetic diversity of PCV2 strains in China.
猪圆环病毒2型（PCV2）是一种重要的猪病原体，已给全球养猪业造成了相当大的经济损失。在2018年至2020年期间，我们在中国山东省对猪进行监测时发现，PCV2感染率为7.89%（86/1090）。此外，我们还发现PCV2经常与猪繁殖与呼吸综合征病毒（PRRSV）、猪瘟病毒（CSFV）和猪疱疹病毒（PRV）发生混合感染。选取13份阳性临床样本扩增PCV2的全基因组并进行测序。在这13份样本中，我们检测到两种基因型：PCV2b（1/13）和PCV2d（12/13）。这表明PCV2d是山东省流行的主要基因型。此外，我们在ORF2区域发现了三个正选择位点，它们位于先前报道的抗原表位位上。这项调查将有助于了解中国PCV2毒株的分子流行病学和遗传多样性。
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