Lis Martyna, Niedziela Natalia, Adamczyk-Zostawa Jowita, Zalejska-Fiolka Jolanta, Szczygieł Jarosław, Sowa Agata, Świętek Agata, Adamczyk-Sowa Monika
Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Curr Issues Mol Biol. 2024 Dec 14;46(12):14119-14131. doi: 10.3390/cimb46120845.
Studies suggest that vitamin D (VitD) may reduce oxidative stress (OS) in multiple sclerosis (MS) patients. This study aimed to compare the effects of various VitD doses on OS in relapsing-remitting MS (RRMS). A 6-month supplementation was introduced using two doses of VitD: 2000 IU/day in the high-dose group (HD, = 23) and 15,960 IU/month in the low-dose group (LD, = 29). Significant differences in body weight, height, and age were found between groups. A significant increase in the level of VitD (25(OH)D) was noted in both groups ( < 0.01). A significant increase was observed in the levels of LF and MDA ( < 0.01) and a significant decrease in the concentrations of PSH ( < 0.01), CuZnSOD ( = 0.02), and TOS ( < 0.01). A significant positive correlation was observed between serum VitD and SOD (R = 0.38, < 0.01) and MnSOD (R = 0.31, < 0.05), as well as a significant negative correlation between serum VitD and MDA (R = -0.31, = 0.05) at the beginning of the study. At the end of the study, a significant positive correlation was observed between serum VitD and SOD (R = 0.34, < 0.05) and CuZnSOD (R = 0.51, < 0.01). In RRMS patients, the VitD doses are probably insufficient to induce a beneficial effect on the pro- and antioxidant balance.
研究表明，维生素D（VitD）可能会降低多发性硬化症（MS）患者的氧化应激（OS）。本研究旨在比较不同剂量的VitD对复发缓解型多发性硬化症（RRMS）患者氧化应激的影响。采用两种剂量的VitD进行为期6个月的补充：高剂量组（HD，n = 23）为2000 IU/天，低剂量组（LD，n = 29）为15960 IU/月。两组在体重、身高和年龄方面存在显著差异。两组的VitD（25(OH)D）水平均显著升高（P < 0.01）。LF和MDA水平显著升高（P < 0.01），PSH、CuZnSOD（P = 0.02）和TOS浓度显著降低（P < 0.01）。在研究开始时，血清VitD与SOD（R = 0.38，P < 0.01）和MnSOD（R = 0.31，P < 0.05）之间存在显著正相关，血清VitD与MDA之间存在显著负相关（R = -0.31，P = 0.05）。在研究结束时，血清VitD与SOD（R = 0.34，P < 0.05）和CuZnSOD（R = 0.51，P < 0.01）之间存在显著正相关。在RRMS患者中，VitD剂量可能不足以对促氧化和抗氧化平衡产生有益影响。
