Komura Yasuo, Kimura Shintarou, Hirasawa Yumi, Katagiri Tomoko, Takaura Ayana, Yoshida Fumika, Fukuro Saki, Muranishi Hiromi, Imataki Osamu, Homma Koichiro
Rinku Medical Clinic, 2F Medical Rinku Port, 3-41 Rinku Ouraiminami, Osaka 598-0047, Japan.
StateArt Inc., 2-9-12 Horidome-cho, Nihonbashi, Chuo-ku, Tokyo 103-0012, Japan.
J Funct Biomater. 2024 Dec 2;15(12):363. doi: 10.3390/jfb15120363.
Photodynamic therapy (PDT) is a minimally invasive treatment that elicits tumor apoptosis using laser light exclusively applied to the tumor site. IR-783, a heptamethine cyanine (HMC) dye, impedes the proliferation of breast cancer cells, even without light. Although studies have investigated the efficacy of IR-783 in cell and animal studies, its efficacy in clinical settings remains unknown. Therefore, we aimed to determine the efficacy of PDT using IR-783 liposomes. An HMC dye, excited by long-wavelength infrared light and with high tissue permeability, was used for PDT after liposomization to enhance tumor tissue accumulation. PDT was performed using IR-783 in two patients with either tongue or breast cancer, one each. IR-783 liposomes inhibited cell proliferation in tongue cancer cells even when not excited by light. Tumor size was markedly reduced in both cases, with no significant adverse events. Furthermore, the patient with tongue cancer exhibited improved respiratory, swallowing, and speech functions, which were attributed not only to the shrinkage of the tumor but also to the improvement in airway narrowing. In conclusion, PDT using IR-783 liposomes effectively reduces tumor size in tongue and breast cancers.
光动力疗法（PDT）是一种微创治疗方法，它通过仅将激光应用于肿瘤部位来引发肿瘤细胞凋亡。IR-783是一种七甲川花菁（HMC）染料，即使在没有光照的情况下也能抑制乳腺癌细胞的增殖。尽管已有研究在细胞和动物实验中探究了IR-783的疗效，但其在临床环境中的疗效仍不明确。因此，我们旨在确定使用IR-783脂质体进行光动力疗法的疗效。一种由长波长红外光激发且具有高组织渗透性的HMC染料，在脂质体化后用于光动力疗法，以增强肿瘤组织的蓄积。对两名分别患有舌癌和乳腺癌的患者使用IR-783进行了光动力疗法。即使在没有光照激发的情况下，IR-783脂质体也能抑制舌癌细胞的增殖。在这两个病例中，肿瘤大小均显著减小，且无明显不良事件。此外，舌癌患者的呼吸、吞咽和言语功能均有所改善，这不仅归因于肿瘤的缩小，还归因于气道狭窄的改善。总之，使用IR-783脂质体进行光动力疗法可有效减小舌癌和乳腺癌的肿瘤大小。
