Grossi-Oliveira Gustavo Augusto, Dallazen Eduardo, Asbi Thabet, Fonseca-Santos João Matheus, Ribeiro-Júnior Paulo Domingos, Shibli Jamil A, Massari Grecco Cinthya, Magro-Filho Osvaldo, Mourão Carlos Fernando, Haim Doron, Mayer Yaniv, Faverani Leonardo P
Department of Diagnosis and Surgery, Division of Oral and Maxillofacial Surgery and Implantology, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, Brazil.
Maccabi-Dent Research Department, Tel-Aviv 6801298, Israel.
J Funct Biomater. 2024 Dec 12;15(12):375. doi: 10.3390/jfb15120375.
This study investigated the effect of platelet-rich fibrin (PRF) on bone healing around implants placed in elevated sinus cavities. Forty New Zealand albino rabbits were divided into eight groups, based on the time of sacrifice (14 or 40 days) and the material used: blood clot (control), hydroxyapatite (HA) from bovine bone, HA combined with PRF, and PRF alone. Each group consisted of five animals (n = 5). A histological analysis measured bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO). The results showed significant increases in the BIC and BAFO values at 40 days compared to 14 days in most groups. At day 14, the HA+PRF group had higher BIC than the clot and the PRF alone groups. At 40 days, HA+PRF maintained the highest BIC across all groups ( < 0.05), though it did not show an advantage for BAFO. These findings indicate that combining HA with PRF promotes better osseointegration around implants placed immediately in maxillary sinus augmentation. Given the limited research on PRF's biological impact, these results underscore the importance of evaluating PRF's role in peri-implant healing and its potential benefits for clinical use in sinus augmentation.
本研究调查了富血小板纤维蛋白（PRF）对在上颌窦提升后植入种植体周围骨愈合的影响。40只新西兰白兔根据处死时间（14天或40天）和使用的材料分为八组：血凝块（对照组）、牛骨来源的羟基磷灰石（HA）、HA联合PRF以及单独使用PRF。每组由五只动物组成（n = 5）。组织学分析测量了骨与种植体的接触（BIC）和骨面积分数占有率（BAFO）。结果显示，与14天时相比，大多数组在40天时BIC和BAFO值显著增加。在第14天，HA+PRF组的BIC高于血凝块组和单独使用PRF组。在第40天，HA+PRF在所有组中保持最高的BIC（<0.05），尽管其在BAFO方面未显示出优势。这些发现表明，将HA与PRF联合使用可促进在上颌窦提升后立即植入的种植体周围更好的骨结合。鉴于对PRF生物学影响的研究有限，这些结果强调了评估PRF在种植体周围愈合中的作用及其在上颌窦提升临床应用中的潜在益处的重要性。
