Kızıldağ Alper, Tasdemir Ufuk, Arabacı Taner, Kızıldağ Canan Aksu, Albayrak Mevlüt, Şahin Barbaros
Department of Periodontology, Faculty of Dentistry, Pamukkale University, Denizli, Turkey.
Department of Maxillofacial Surgery, Faculty of Dentistry, Pamukkale University, Denizli, Turkey.
J Oral Implantol. 2020 Jun 1;46(3):221-226. doi: 10.1563/aaid-joi-D-19-00038.
The aim of this study was to evaluate the effect of autogenous tooth bone graft (ATBG) combined with platelet-rich fibrin (PRF) on bone healing in rabbit peri-implant osseous defects. Eighteen New Zealand rabbits were divided into 3 groups. Bone defects were prepared in each rabbit, and then an implant cavity was created in the defects. Dental implants were placed, and the peri-implant bone defects were treated with the following 3 methods: no graft material was applied in the control group, bone defects were treated with ATBG in the ATBG group, and bone defects were treated with ATBG combined with PRF in the ATBG+PRF group. After 28 days, the rabbits were sacrificed, and the dental implants with surrounding bone were removed. New bone formation and the percentage of bone-to-implant contact (BIC) were determined with histomorphometric evaluations. New bone formation was significantly higher in the ATBG+PRF group than the control and ATBG groups (P < .05). In addition, BIC was significantly higher in the ATBG+PRF group than in the control and ATBG groups (P < .05). The combination of ATBG with PRF contributed to bone healing in rabbits with peri-implant bone defects.
本研究旨在评估自体牙骨移植（ATBG）联合富血小板纤维蛋白（PRF）对兔种植体周围骨缺损骨愈合的影响。将18只新西兰兔分为3组。在每只兔身上制备骨缺损，然后在缺损处创建种植窝。植入牙种植体，种植体周围骨缺损采用以下3种方法治疗：对照组不应用移植材料，ATBG组用ATBG治疗骨缺损，ATBG + PRF组用ATBG联合PRF治疗骨缺损。28天后，处死兔子，取出带有周围骨组织的牙种植体。通过组织形态计量学评估确定新骨形成情况和骨与种植体接触率（BIC）。ATBG + PRF组的新骨形成明显高于对照组和ATBG组（P < 0.05）。此外，ATBG + PRF组的BIC明显高于对照组和ATBG组（P < 0.05）。ATBG与PRF联合应用有助于兔种植体周围骨缺损的骨愈合。
