从……分离出的内生真菌FL7中发现的新型聚酮合酶/非核糖体肽合成酶tenuazamines A-H
New PKS/NRPS Tenuazamines A-H from the Endophytic Fungus FL7 Isolated from .
作者信息
Zhang Hao, Zhang Zhibin, Xiao Yiwen, Wang Wen, Gao Boliang, Xie Yuhao, Xie Jiahao, Gao Xinhua, Zhu Du
机构信息
Jiangxi Province Key Laboratory of Natural Microbial Medicine Research, Key Laboratory of Microbial Resources and Metabolism of Nanchang City, College of Life Sciences, Jiangxi Science and Technology Normal University, Nanchang 330013, China.
Jiangxi Province Key Laboratory of Biodiversity Conservation and Bioresource Utilization, School of Life Sciences, Jiangxi Normal University, Nanchang 330022, China.
出版信息
J Fungi (Basel). 2024 Nov 21;10(12):809. doi: 10.3390/jof10120809.
In this paper, we present a novel class of hybrid polyketides, tenuazamines A-H (-), which exhibit a unique tautomeric equilibrium from FL7. The elucidation of the structures was achieved through a diverse combination of NMR, HR-ESIMS, and ECD methods, with a focus on extensive spectroscopic data analysis. Notably, compounds , , - exhibited potent toxic effects on the growth of . This research expands the structural diversity of tenuazonic acid compounds derived from endophytic fungi and provides potential hit compounds for the development of herbicides.
在本文中，我们提出了一类新型的杂合聚酮化合物，即细交链孢胺A-H（-），它们呈现出源于FL7的独特互变异构平衡。通过核磁共振（NMR）、高分辨电喷雾电离质谱（HR-ESIMS）和电子圆二色光谱（ECD）方法的多种组合，并着重于广泛的光谱数据分析，实现了结构的阐明。值得注意的是，化合物 、 、 - 对 的生长表现出强烈的毒性作用。本研究扩展了源自内生真菌的细交链孢菌酸化合物的结构多样性，并为除草剂的开发提供了潜在的先导化合物。
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