Tamersit Khalil, Kouzou Abdellah, Rodriguez José, Abdelrahem Mohamed
National School of Nanoscience and Nanotechnology, Abdelhafid Ihaddaden Scientific and Technological Hub, Sidi Abdellah, Algiers 16000, Algeria.
Laboratory of Inverse Problems, Modeling, Information and Systems (PIMIS), Université 8 Mai 1945 Guelma, Guelma 24000, Algeria.
Nanomaterials (Basel). 2024 Dec 19;14(24):2038. doi: 10.3390/nano14242038.
In this paper, a new label-free DNA nanosensor based on a top-gated (TG) metal-ferroelectric-metal (MFM) graphene nanoribbon field-effect transistor (TG-MFM GNRFET) is proposed through a simulation approach. The DNA sensing principle is founded on the dielectric modulation concept. The computational method employed to evaluate the proposed nanobiosensor relies on the coupled solutions of a rigorous quantum simulation with the Landau-Khalatnikov equation, considering ballistic transport conditions. The investigation analyzes the effects of DNA molecules on nanodevice behavior, encompassing potential distribution, ferroelectric-induced gate voltage amplification, transfer characteristics, subthreshold swing, and current ratio. It has been observed that the feature of ferroelectric-induced gate voltage amplification using the integrated MFM structure can significantly enhance the biosensor's sensitivity to DNA molecules, whether in terms of threshold voltage shift or drain current variation. Additionally, we propose the current ratio as a sensing metric due to its ability to consider all DNA-induced modulations of electrical parameters, specifically the increase in on-state current and the decrease in off-state current and subthreshold swing. The obtained results indicate that the proposed negative-capacitance GNRFET-based DNA nanosensor could be considered an intriguing option for advanced point-of-care testing.
本文通过模拟方法提出了一种基于顶栅（TG）金属-铁电体-金属（MFM）石墨烯纳米带场效应晶体管（TG-MFM GNRFET）的新型无标记DNA纳米传感器。DNA传感原理基于介电调制概念。用于评估所提出的纳米生物传感器的计算方法依赖于在考虑弹道输运条件下，将严格的量子模拟与朗道-哈拉特尼科夫方程的耦合解。该研究分析了DNA分子对纳米器件行为的影响，包括电位分布、铁电诱导的栅极电压放大、转移特性、亚阈值摆幅和电流比。已经观察到，使用集成MFM结构的铁电诱导栅极电压放大特性可以显著提高生物传感器对DNA分子的灵敏度，无论是在阈值电压偏移还是漏极电流变化方面。此外，由于电流比能够考虑所有DNA诱导的电参数调制，特别是导通状态电流的增加、截止状态电流的减小和亚阈值摆幅，我们提出将电流比作为一种传感指标。所得结果表明，所提出的基于负电容GNRFET的DNA纳米传感器可被视为先进的即时检测的一个有趣选择。
