氙气和氪气对大鼠局部脑血流量的影响。

Effects of xenon and krypton on regional cerebral blood flow in the rat.

作者信息

Junck L, Dhawan V, Thaler H T, Rottenberg D A

出版信息

J Cereb Blood Flow Metab. 1985 Mar;5(1):126-32. doi: 10.1038/jcbfm.1985.16.

DOI:10.1038/jcbfm.1985.16

Abstract

The effects of high inspired concentrations of xenon and krypton on regional CBF (rCBF) were assessed in the rat using [14C]iodoantipyrine and quantitative autoradiography. Inhalation of 80% xenon for 1 or 2 min and inhalation of 40% xenon for 2 min were found to have significant effects on rCBF, including average increases of 75-96% in cerebral neocortical regions. Inhalation of 40% xenon for 1 min and of 80% krypton for 2 min had no significant effect on rCBF in most brain regions studied. If xenon inhalation produces effects on rCBF in humans similar to those observed in the rat, such effects could be an important source of error in xenon computed tomography rCBF studies.

摘要

采用[¹⁴C]碘安替比林和定量放射自显影技术，在大鼠中评估了高吸入浓度的氙气和氪气对局部脑血流量（rCBF）的影响。发现吸入80%氙气1或2分钟以及吸入40%氙气2分钟对rCBF有显著影响，包括大脑新皮质区域平均增加75 - 96%。在大多数研究的脑区中，吸入40%氙气1分钟和吸入80%氪气2分钟对rCBF没有显著影响。如果氙气吸入对人类rCBF产生的影响与在大鼠中观察到的相似，那么这种影响可能是氙气计算机断层扫描rCBF研究中一个重要的误差来源。