Holl K, Nemati N, Kohmura E, Gaab M R, Samii M
Department of Neurosurgery, Nordstadt Hospital, Hannover, Federal Republic of Germany.
Acta Neurochir (Wien). 1987;87(3-4):129-33. doi: 10.1007/BF01476063.
The effects of inhalation of a 33% Xenon-O2 mixture over a period of 5 minutes on EEG and cardio-respiratory parameters were studied in 18 human volunteers. This dosage is similar to that used clinically in Xenon-CT studies. In 4 cases no EEG power change was observed during the study. In the 14 other subjects EEG variations were seen. The most prominent change was an increase in beta EEG power. No change was observed in theta and delta EEG power. The findings seem to correlate with the early induction (excitation) phase of an anaesthetic. Hyperventilation was observed before the study and increased during the Xenon inhalation. Blood pressure remained stable while the heart rate tended to decrease a little. All these changes disappeared rapidly following the termination of the Xenon inhalation. The effects are minimal and should not reduce the clinical value of CBF measurement using the Xenon-CT method.
在18名人类志愿者身上研究了吸入33%氙气 - 氧气混合气体5分钟对脑电图（EEG）和心肺参数的影响。该剂量与氙增强CT（Xenon - CT）研究中临床使用的剂量相似。在4例受试者中，研究期间未观察到脑电图功率变化。在其他14名受试者中观察到了脑电图变化。最显著的变化是脑电图β波功率增加。脑电图θ波和δ波功率未观察到变化。这些发现似乎与麻醉的早期诱导（兴奋）阶段相关。在研究前观察到过度通气，且在吸入氙气期间增加。血压保持稳定，而心率略有下降趋势。氙气吸入终止后，所有这些变化迅速消失。这些影响很小，不应降低使用氙增强CT方法测量脑血流量（CBF）的临床价值。
