冠心病患者中n-6:n-3多不饱和脂肪酸（PUFA）摄入比例与血清氧化高密度脂蛋白（oxHDL）/高密度脂蛋白胆固醇（HDL-c）比例之间呈正相关。

Positive correlation between n- 6 : n- 3 PUFA ratio intake with serum oxHDL/HDL-c ratio in patients with coronary artery disease.

作者信息

Godinez-Mora Sissi, Campos-Perez Wendy, Perez-Robles Mariana, Robles-Jimarez Cesar, Muñoz-Hernandez Alejandra, Torres-Vanegas Joel, Martinez-Lopez Erika

机构信息

Departamento de Biología Molecular y Genómica, Instituto de Nutrigenética y Nutrigenómica Traslacional.

Doctorado en Ciencias de la Nutrición Traslacional, Departamento de la Reproducción Humana, Crecimiento y Desarrollo Infantil, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.

出版信息

Coron Artery Dis. 2025 May 1;36(3):190-199. doi: 10.1097/MCA.0000000000001437. Epub 2024 Oct 16.

DOI:10.1097/MCA.0000000000001437

PMID:39729580

Abstract

BACKGROUND

Coronary artery disease (CAD) is one of the most prevalent cardiovascular diseases where serum lipoprotein oxidation plays a significant role. Polyunsaturated fatty acids (PUFA) n -6 : n -3 unbalance ratio consumption, affects lipoprotein oxidation, and inflammation processes. This study aimed to analyze the relationship between n -6 : n -3 PUFA ratio intake with oxidized lipoproteins in individuals with CAD.

METHODS

A cross-sectional study was performed including 105 subjects (51 diagnosed with CAD and 54 non-CAD) from western Mexico. Dietary information was collected using a habitual day food record. Serum oxidized low-density lipoprotein (oxLDL) and oxidized high-density lipoprotein (oxHDL) concentrations were quantified by enzyme linked immunosorbent assay.

RESULTS

CAD subjects had higher oxHDL/HDL cholesterol (HDL-c) ratio [0.102 (0.092-0.112) vs. 0.080 (0.070-0.090), P = 0.004] and oxLDL/LDL cholesterol (LDL-c) ratio [129.2 (108-150.4) vs. 59.7 (39.3-80), P < 0.001] compared to non-CAD subjects. Risk factors associated with CAD were a high n -6 : n -3 PUFA ratio (odds ratio, OR = 2.3, P = 0.046), hypoalphalipoproteinemia in men (OR = 3.2, P = 0.014), moderate/high tobacco index (OR = 6.33, P = 0.003), elevated waist circumference in women (OR = 7, P = 0.004), hypertension (OR = 21.14, P < 0.001), and type 2 diabetes (OR: 25, P < 0.001). The oxHDL/HDL-c ratio was positively associated with the n -6 : n -3 PUFA ratio [ r2 = 28.3, B = 0.002 (0.001-0.003), P < 0.001] in CAD patients.

CONCLUSIONS

This study showed that a higher n -6 : n -3 PUFA ratio intake correlates with higher serum oxHDL/HDL-c in CAD patients.

摘要

背景

冠状动脉疾病（CAD）是最常见的心血管疾病之一，血清脂蛋白氧化在其中起着重要作用。多不饱和脂肪酸（PUFA）n -6∶n -3的不均衡摄入会影响脂蛋白氧化及炎症过程。本研究旨在分析CAD患者中n -6∶n -3多不饱和脂肪酸比例摄入量与氧化型脂蛋白之间的关系。

方法

进行了一项横断面研究，纳入了来自墨西哥西部的105名受试者（51名被诊断为CAD，54名未患CAD）。通过记录日常饮食来收集饮食信息。采用酶联免疫吸附测定法定量血清氧化型低密度脂蛋白（oxLDL）和氧化型高密度脂蛋白（oxHDL）浓度。

结果

与未患CAD的受试者相比，CAD患者的oxHDL/高密度脂蛋白胆固醇（HDL-c）比值更高[0.102（0.092 - 0.112）对0.080（0.070 - 0.090），P = 0.004]，oxLDL/低密度脂蛋白胆固醇（LDL-c）比值更高[129.2（108 - 150.4）对59.7（39.3 - 80），P < 0.001]。与CAD相关的危险因素包括高n -6∶n -3多不饱和脂肪酸比例（比值比，OR = 2.3，P = 0.046）、男性低α脂蛋白血症（OR = 3.2，P = 0.014）、中度/高度烟草指数（OR = 6.33，P = 0.003）、女性腰围增加（OR = 7，P = 0.004）、高血压（OR = 21.14，P < 0.001）和2型糖尿病（OR：25，P < 0.001）。在CAD患者中，oxHDL/HDL-c比值与n -6∶n -3多不饱和脂肪酸比例呈正相关[r2 = 28.3，B = 0.002（0.001 - 0.003），P < 0.001]。