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卵巢储备功能下降的中西医治疗进展

Treatment Progress in Diminished Ovarian Reserve: Western and Chinese Medicine.

作者信息

Zhang Qiao-Li, Lei Ya-Ling, Deng Yan, Ma Rui-Lin, Ding Xue-Song, Xue Wei, Sun Ai-Jun

机构信息

Department of Human Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, China.

Department of Encephalopathy, Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, 710000, China.

出版信息

Chin J Integr Med. 2023 Apr;29(4):361-367. doi: 10.1007/s11655-021-3353-2. Epub 2022 Jan 11.

DOI:10.1007/s11655-021-3353-2
PMID:35015221
Abstract

Diminished ovarian reserve (DOR), generally defined as a decreased number or quality of oocytes, has a significant impact on quality of life and fertility in women. In recent years, the incidence of DOR has been increasing and the ages of patients are younger. The search for an effective DOR treatment has emerged as one of the preeminent research topics in reproductive health. An effective DOR therapy would improve ovarian function, fertility, and quality of life in patients. In this review we evaluated DOR treatment progress both in Western medicine and Chinese medicine, and elucidated the characteristics of each treatment.

摘要

卵巢储备功能减退(DOR),通常定义为卵母细胞数量减少或质量下降,对女性的生活质量和生育能力有重大影响。近年来,DOR的发病率一直在上升,且患者年龄呈年轻化趋势。寻找有效的DOR治疗方法已成为生殖健康领域的首要研究课题之一。有效的DOR治疗方法将改善患者的卵巢功能、生育能力和生活质量。在本综述中,我们评估了中西医治疗DOR的进展,并阐明了每种治疗方法的特点。

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Ferroptosis and Sterol Biosynthesis Dysregulation in Granulosa Cells of Patients with Diminished Ovarian Reserve.卵巢储备功能减退患者颗粒细胞中的铁死亡与固醇生物合成失调
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4D quantitative proteomics of ovarian granulosa cells reveals the involvement of oxidative phosphorylation in non-elderly women with diminished ovarian reserve.

本文引用的文献

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Therapeutic importance of Zishen Yutai Pill on the female reproductive health: A review.滋肾育胎丸对女性生殖健康的治疗重要性:综述。
J Ethnopharmacol. 2021 Dec 5;281:114523. doi: 10.1016/j.jep.2021.114523. Epub 2021 Aug 24.
2
Network Pharmacology Approach for Predicting Targets of Zishen Yutai Pills on Premature Ovarian Insufficiency.基于网络药理学方法预测滋肾育胎丸治疗卵巢早衰的靶点
Evid Based Complement Alternat Med. 2021 Aug 4;2021:8215454. doi: 10.1155/2021/8215454. eCollection 2021.
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Qilin Pill Exerts Therapeutic Effect on Resection-Induced Premature Ovarian Insufficiency Rats by Inhibiting the MAPK and PI3K-AKT Signaling Pathways.
卵巢颗粒细胞的4D定量蛋白质组学揭示了氧化磷酸化在卵巢储备功能减退的非老年女性中的作用。
J Ovarian Res. 2025 May 20;18(1):104. doi: 10.1186/s13048-025-01688-1.
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The role of Chinese herbal medicine in diminished ovarian reserve management.中药在卵巢储备功能减退管理中的作用
J Ovarian Res. 2025 Apr 30;18(1):90. doi: 10.1186/s13048-025-01669-4.
5
Huyang Yangkun Formula Enhances Ovarian Function and Delays Reproductive Aging by Influencing Hypothalamic GnRH/LH Pulse Release Through GAT-1/GABA/GABAAR2.胡杨养坤方通过GAT-1/γ-氨基丁酸/GABAAR2影响下丘脑促性腺激素释放激素/促黄体生成素脉冲释放,从而增强卵巢功能并延缓生殖衰老。
Drug Des Devel Ther. 2025 Apr 9;19:2677-2691. doi: 10.2147/DDDT.S504610. eCollection 2025.
6
Zishen Yutai pill ameliorates ovarian reserve by mediating PI3K-Akt pathway and apoptosis level in ovary.滋肾育胎丸通过介导PI3K-Akt通路及卵巢细胞凋亡水平改善卵巢储备功能。
J Ovarian Res. 2025 Mar 24;18(1):61. doi: 10.1186/s13048-025-01643-0.
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Sci Rep. 2024 Dec 28;14(1):30799. doi: 10.1038/s41598-024-81033-6.
麒麟丸通过抑制 MAPK 和 PI3K-AKT 信号通路对卵巢切除诱导的早发性卵巢功能不全大鼠发挥治疗作用。
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