Hsu Fang-Chin, Weng Tzu-Hsuan, Pu Ta-Wei, Chang Pi-Kai, Lin Tzu-Chiao, Jao Shu-Wen, Chen Chao-Yang, Hu Je-Ming, Chien Wu-Chien
Division of Colorectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Sci Rep. 2024 Dec 28;14(1):30968. doi: 10.1038/s41598-024-81950-6.
Infectious intestinal diseases (IIDs) pose a significant health and economic burden worldwide. Recent observations at the Tri-Service General Hospital, Taiwan, suggest a potential association between IIDs and neurodegenerative diseases, prompting an investigation into this relationship. This study explored interactions between IIDs and neurodegenerative diseases. We conducted a population-based retrospective cohort analysis using data from the National Health Insurance Research Database (NHIRD) of Taiwan. Patients diagnosed with IIDs between 2000 and 2015 were identified along with a matched control group. Covariates, including demographics, comorbidities, and healthcare utilization were considered. The hazard ratios (HRs) of neurodegenerative diseases were assessed using a Cox proportional regression analysis. This study included 297,438 patients: 99,146 and 198,292 patients in the IID and control groups, respectively. Patients with IIDs showed a significantly higher overall risk of neurodegenerative diseases (adjusted hazard ratio [aHR] = 1.144, P < 0.001). Subgroup analyses revealed an elevated risk of Parkinson's disease, multiple sclerosis, and other neurodegeneration-associated disorders in the study group. Additionally, a positive correlation was observed between the frequency of medical visits for IIDs and neurodegenerative disease risk. This study provides evidence for a significant association between IIDs and the neurodegenerative disease risk. Early detection and management of IIDs may have implications for long-term neurological health outcomes. Further research is required to elucidate underlying mechanisms and develop targeted interventions and preventive strategies.
感染性肠道疾病（IIDs）在全球范围内造成了重大的健康和经济负担。台湾三军总医院最近的观察结果表明，IIDs与神经退行性疾病之间可能存在关联，这促使人们对这种关系进行调查。本研究探讨了IIDs与神经退行性疾病之间的相互作用。我们使用台湾国民健康保险研究数据库（NHIRD）的数据进行了一项基于人群的回顾性队列分析。确定了2000年至2015年间被诊断为IIDs的患者以及一个匹配的对照组。考虑了协变量，包括人口统计学、合并症和医疗保健利用情况。使用Cox比例回归分析评估神经退行性疾病的风险比（HRs）。本研究纳入了297,438名患者：IID组和对照组分别有99,146名和198,292名患者。IIDs患者患神经退行性疾病的总体风险显著更高（调整后的风险比[aHR]=1.144，P<0.001）。亚组分析显示，研究组中帕金森病、多发性硬化症和其他神经退行性相关疾病的风险升高。此外，观察到IIDs就诊频率与神经退行性疾病风险之间存在正相关。本研究为IIDs与神经退行性疾病风险之间的显著关联提供了证据。IIDs的早期检测和管理可能对长期神经健康结果有影响。需要进一步研究以阐明潜在机制，并制定有针对性的干预措施和预防策略。
