Department of Colorectal and Anal Surgery, The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, China.
Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Acta Neurol Scand. 2022 Apr;145(4):442-448. doi: 10.1111/ane.13570. Epub 2021 Dec 15.
Growing evidence suggests that irritable bowel syndrome (IBS) and Parkinson's disease (PD) share similar pathological mechanisms and risk factors.
We performed a systematic review and meta-analysis of the evidence for a relationship between IBS and PD. Risk estimates from individual studies were pooled using random-effects models.
Six articles involving 58,645 patients with PD were included in our meta-analysis. The overall risk for PD in IBS patients was significantly higher than that in the general population (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.29-1.75; p < .001). Subgroup analysis revealed no significant differences in risk between men (OR = 1.47, 95% CI: 1.3-1.67; p < .001) and women (OR = 1.51, 95% CI: 1.29-1.75; p < .001); however, older (≥65 years) IBS patients (OR = 1.44, 95% CI: 1.3-1.59; p < .001) may be at higher risk for PD than younger (40-64 years) patients (OR = 1.32, 95% CI: 1.05-1.64; p = .017).
Overall, the PD risk was higher in IBS patients than others, indicating that the intestinal disorder may serve as a warning sign for PD.
越来越多的证据表明，肠易激综合征（IBS）和帕金森病（PD）具有相似的病理机制和风险因素。
我们对 IBS 与 PD 之间关系的证据进行了系统回顾和荟萃分析。使用随机效应模型对来自个体研究的风险估计值进行了汇总。
我们的荟萃分析纳入了 6 项涉及 58645 例 PD 患者的研究。IBS 患者发生 PD 的总体风险明显高于普通人群（比值比 [OR]，1.5；95%置信区间 [CI]，1.29-1.75；p<0.001）。亚组分析显示，男性（OR=1.47，95%CI：1.3-1.67；p<0.001）和女性（OR=1.51，95%CI：1.29-1.75；p<0.001）之间的风险无显著差异；然而，年龄较大（≥65 岁）的 IBS 患者（OR=1.44，95%CI：1.3-1.59；p<0.001）发生 PD 的风险可能高于年龄较小（40-64 岁）的患者（OR=1.32，95%CI：1.05-1.64；p=0.017）。
总体而言，IBS 患者发生 PD 的风险高于其他人，这表明肠道疾病可能是 PD 的预警信号。
