肠道微生物群失调：触发因素、后果、诊断与治疗选择
Gut Microbiota Dysbiosis: Triggers, Consequences, Diagnostic and Therapeutic Options.
作者信息
Hrncir Tomas
机构信息
The Institute of Microbiology, The Czech Academy of Sciences, 549 22 Novy Hradek, Czech Republic.
出版信息
Microorganisms. 2022 Mar 7;10(3):578. doi: 10.3390/microorganisms10030578.
Abstract
The global incidence of numerous immune-mediated, metabolic, neurodegenerative, and psychiatric diseases is steadily increasing [...].
摘要
许多免疫介导性、代谢性、神经退行性和精神性疾病的全球发病率正在稳步上升[……]。
相似文献
1
Gut Microbiota Dysbiosis: Triggers, Consequences, Diagnostic and Therapeutic Options.肠道微生物群失调：触发因素、后果、诊断与治疗选择
Microorganisms. 2022 Mar 7;10(3):578. doi: 10.3390/microorganisms10030578.
2
Food Preservatives Induce Dysbiosis in Human-Microbiota Associated -Deficient Mice.食品防腐剂会在人源微生物群相关缺陷小鼠中引发生态失调。
Microorganisms. 2019 Sep 23;7(10):383. doi: 10.3390/microorganisms7100383.
3
Exercise, diet and stress as modulators of gut microbiota: Implications for neurodegenerative diseases.运动、饮食和压力作为肠道微生物群的调节剂：对神经退行性疾病的影响。
Neurobiol Dis. 2020 Feb;134:104621. doi: 10.1016/j.nbd.2019.104621. Epub 2019 Oct 16.
4
Gut Microbiota Regulate Astrocytic Functions in the Brain: Possible Therapeutic Consequences.肠道微生物群调控大脑中的星形胶质细胞功能：可能的治疗后果。
Curr Neuropharmacol. 2021;19(8):1354-1366. doi: 10.2174/1570159X19666210215123239.
5
Gut Microbiota and Alzheimer's Disease: Pathophysiology and Therapeutic Perspectives.肠道微生物群与阿尔茨海默病：病理生理学和治疗视角。
J Alzheimers Dis. 2021;83(3):963-976. doi: 10.3233/JAD-210381.
6
Dysbiosis is one of the risk factor for stroke and cognitive impairment and potential target for treatment.肠道菌群失调是中风和认知障碍的危险因素之一，也是潜在的治疗靶点。
Pharmacol Res. 2021 Feb;164:105277. doi: 10.1016/j.phrs.2020.105277. Epub 2020 Nov 7.
7
Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders.肠道微生物群失调介导的神经免疫失调以及慢性神经退行性疾病发病机制中蛋白质错误折叠和清除的机制性见解。
Front Neurosci. 2022 Feb 25;16:836605. doi: 10.3389/fnins.2022.836605. eCollection 2022.
8
Metabolic Influences of Gut Microbiota Dysbiosis on Inflammatory Bowel Disease.肠道微生物群失调对炎症性肠病的代谢影响
Front Physiol. 2021 Sep 27;12:715506. doi: 10.3389/fphys.2021.715506. eCollection 2021.
9
The role of gut microbiota in intestinal and liver diseases.肠道微生物群在肠道和肝脏疾病中的作用。
Lab Anim. 2019 Jun;53(3):271-280. doi: 10.1177/0023677218818605. Epub 2018 Dec 22.
10
Nutritional and therapeutic approaches for protecting human gut microbiota from psychotropic treatments.保护人类肠道微生物群免受精神类治疗影响的营养和治疗方法。
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jun 8;108:110182. doi: 10.1016/j.pnpbp.2020.110182. Epub 2020 Nov 21.
引用本文的文献
1
Gut Microbiota-Derived Metabolites in Atherosclerosis: Pathways, Biomarkers, and Targets.肠道微生物群衍生代谢产物在动脉粥样硬化中的作用：途径、生物标志物和靶点
Int J Mol Sci. 2025 Sep 1;26(17):8488. doi: 10.3390/ijms26178488.
2
Food Preservatives and the Rising Tide of Early-Onset Colorectal Cancer: Mechanisms, Controversies, and Emerging Innovations.食品防腐剂与早发性结直肠癌的上升趋势：作用机制、争议及新出现的创新方法
Foods. 2025 Sep 1;14(17):3079. doi: 10.3390/foods14173079.
3
Enhanced metagenomic strategies for elucidating the complexities of gut microbiota: a review.用于阐明肠道微生物群复杂性的增强宏基因组学策略：综述
Front Microbiol. 2025 Aug 26;16:1626002. doi: 10.3389/fmicb.2025.1626002. eCollection 2025.
4
Immune Modulation by Microbiota and Its Possible Impact on Polyomavirus Infection.微生物群介导的免疫调节及其对多瘤病毒感染的潜在影响
Pathogens. 2025 Jul 30;14(8):747. doi: 10.3390/pathogens14080747.
5
High Schistosoma mansoni infection intensity is associated with distinct gut microbiota and low levels of systemic cytokines in children along the Albert-Nile, Northern Uganda.在乌干达北部阿尔伯特尼罗河沿岸的儿童中，曼氏血吸虫高感染强度与独特的肠道微生物群和低水平的全身细胞因子有关。
BMC Microbiol. 2025 Aug 14;25(1):506. doi: 10.1186/s12866-025-04252-5.
6
Creation of Zinc (II)-Complexed Green Tea and Its Effects on Gut Microbiota by Daily Green Tea Consumption.锌（II）复合绿茶的制备及其通过每日饮用绿茶对肠道微生物群的影响。
Molecules. 2025 Jul 30;30(15):3191. doi: 10.3390/molecules30153191.
7
Demographic drivers of gut microbiome diversity.肠道微生物群多样性的人口统计学驱动因素。
AMB Express. 2025 Aug 8;15(1):115. doi: 10.1186/s13568-025-01921-6.
8
Impact of gastrointestinal dysbiosis on tryptophan metabolism and neurological cancer progression.胃肠道生态失调对色氨酸代谢及神经肿瘤进展的影响。
Med Oncol. 2025 Aug 6;42(9):412. doi: 10.1007/s12032-025-02972-2.
9
[Prebiotics, probiotics and postbiotics-An introduction].[益生元、益生菌和后生元——简介]
HNO. 2025 Aug 5. doi: 10.1007/s00106-025-01657-6.
10
Modulating the Gut Microbiota to Target Neuroinflammation, Cognition and Mood: A Systematic Review of Human Studies with Relevance to Fibromyalgia.调节肠道微生物群以靶向神经炎症、认知和情绪：与纤维肌痛相关的人体研究的系统评价
Nutrients. 2025 Jul 9;17(14):2261. doi: 10.3390/nu17142261.
本文引用的文献
1
Role of Gut Microbiome in COVID-19: An Insight Into Pathogenesis and Therapeutic Potential.肠道微生物组在 COVID-19 中的作用：对发病机制和治疗潜力的深入了解。
Front Immunol. 2021 Oct 14;12:765965. doi: 10.3389/fimmu.2021.765965. eCollection 2021.
2
Long-Term Follow-Up Results of Fecal Microbiota Transplantation for Irritable Bowel Syndrome: A Single-Center, Retrospective Study.肠易激综合征粪便微生物群移植的长期随访结果：一项单中心回顾性研究
Front Med (Lausanne). 2021 Jul 30;8:710452. doi: 10.3389/fmed.2021.710452. eCollection 2021.
3
Gut Microbiota and NAFLD: Pathogenetic Mechanisms, Microbiota Signatures, and Therapeutic Interventions.肠道微生物群与非酒精性脂肪性肝病：发病机制、微生物群特征及治疗干预
Microorganisms. 2021 Apr 29;9(5):957. doi: 10.3390/microorganisms9050957.
4
The Impact of a Dried Fruit and Vegetable Supplement and Fiber Rich Shake on Gut and Health Parameters in Female Healthcare Workers: A Placebo-Controlled, Double-Blind, Randomized Clinical Trial.一种果蔬干补充剂和富含纤维奶昔对女性医护人员肠道及健康参数的影响：一项安慰剂对照、双盲、随机临床试验
Microorganisms. 2021 Apr 14;9(4):843. doi: 10.3390/microorganisms9040843.
5
Changes in Gut Microbiota after a Four-Week Intervention with Vegan vs. Meat-Rich Diets in Healthy Participants: A Randomized Controlled Trial.健康参与者采用纯素饮食与富含肉类饮食进行四周干预后肠道微生物群的变化：一项随机对照试验。
Microorganisms. 2021 Mar 31;9(4):727. doi: 10.3390/microorganisms9040727.
6
Fecal Microbiome and Resistome Profiling of Healthy and Diseased Pakistani Individuals Using Next-Generation Sequencing.利用下一代测序技术对健康和患病的巴基斯坦个体进行粪便微生物组和耐药组分析
Microorganisms. 2021 Mar 17;9(3):616. doi: 10.3390/microorganisms9030616.
7
Kale Attenuates Inflammation and Modulates Gut Microbial Composition and Function in C57BL/6J Mice with Diet-Induced Obesity.羽衣甘蓝可减轻饮食诱导肥胖的C57BL/6J小鼠的炎症，并调节其肠道微生物组成和功能。
Microorganisms. 2021 Jan 24;9(2):238. doi: 10.3390/microorganisms9020238.
8
Faecal microbiota transplantation for recurrent infection: An updated systematic review and meta-analysis.粪便微生物群移植治疗复发性感染：一项更新的系统评价和荟萃分析。
EClinicalMedicine. 2020 Nov 23;29-30:100642. doi: 10.1016/j.eclinm.2020.100642. eCollection 2020 Dec.
9
Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19.肠道微生物群落组成反映了 COVID-19 患者的疾病严重程度和功能失调的免疫反应。
Gut. 2021 Apr;70(4):698-706. doi: 10.1136/gutjnl-2020-323020. Epub 2021 Jan 11.
10
Burden of Neurological Disorders Across the US From 1990-2017: A Global Burden of Disease Study.《1990-2017 年美国神经障碍疾病负担：全球疾病负担研究》
JAMA Neurol. 2021 Feb 1;78(2):165-176. doi: 10.1001/jamaneurol.2020.4152.
Zotero 插件