MozafaryBazargany MohammadHossein, Khalili Pour Elias, Shamsedini Ali, Banifatemeh Seyed Ali, Azimi Amir, Manavishad Amir, Sadr Saeed, Sadeghipour Parham, Firouzi Ata, Elahifar Armin, Baay Mohammadreza, Alemzadeh-Ansari Mohammad Javad, Mahdizad Zahra, Faghihi Hooshang, Asadigandomani Hassan, Gholami Niloofar, Adimi Sara, Khalilipur Ehsan, Mirshahi Reza, Riazi-Esfehani Hamid
Rajaie Cardiovascular Medical and Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Retina Ward, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Sci Rep. 2024 Dec 28;14(1):31090. doi: 10.1038/s41598-024-82118-y.
We compared chorioretinal microvascular of Slow Coronary Flow Phenomenon (SCFP) patients using Optical Coherence Tomography Angiography (OCTA) to healthy controls. We recruited 21 patients from September 2023 until January 2024 from two referral centers. We enrolled 21 age-sex-matched controls retrospectively. Patients were referred to obtain OCTA in our outpatient ophthalmology clinic. The OCTA and Enhanced Depth Imaging (EDI) OCT findings were measured. Whole image and perifoveal Vascular Density (VD) of superficial and deep capillary plexuses and Parafoveal VD of superficial layer were diminished in SCFP groups compared to controls (p < 0.05) while both superficial and deep foveal VD and deep parafoveal VD were spared. Sub-Foveal Choroidal Thickness (SFCT) was significantly thinned compared to controls (p < 0.05), while central macular thickness, choroidal vascularity index, and choriocapillaris flow were similar between groups. SFCT was the only independent predictor of SCFP on multivariable regression analysis. Parafoveal superficial VD and SFCT showed the strongest ability to distinguish between SCFP patients and healthy controls (AUC: 0.80, 0.79, respectively). Additionally, whole image and perifoveal VD in both superficial and deep capillary plexus demonstrated at least moderate discriminatory power. We found that decreased retinal microvascular density may serve as a potential biomarker for the diagnosis of SCFP. Additionally, SCFP patients had considerably thinner SFCTs than controls. Parafoveal superficial VD and SFCT showed the highest potential in distinguishing between individuals with SCFP and healthy individuals. SCFP is likely linked to anomalies in the small blood vessels of the retina and choroid. However, further studies are needed to confirm this association and to control for the potential confounding effects of diabetes and hypertension.
我们使用光学相干断层扫描血管造影（OCTA）对缓慢冠状动脉血流现象（SCFP）患者的脉络膜视网膜微血管与健康对照者进行了比较。从2023年9月至2024年1月，我们从两个转诊中心招募了21例患者。我们回顾性纳入了21例年龄和性别匹配的对照者。患者被转诊至我们的眼科门诊以进行OCTA检查。对OCTA和增强深度成像（EDI）OCT检查结果进行了测量。与对照组相比，SCFP组的全层图像以及浅层和深层毛细血管丛的中心凹周围血管密度（VD）以及浅层的中心凹旁VD均降低（p < 0.05），而中心凹浅层和深层VD以及深层中心凹旁VD未受影响。与对照组相比，中心凹下脉络膜厚度（SFCT）显著变薄（p < 0.05），而两组之间的中心黄斑厚度、脉络膜血管指数和脉络膜毛细血管血流相似。在多变量回归分析中，SFCT是SCFP的唯一独立预测因素。中心凹旁浅层VD和SFCT区分SCFP患者和健康对照者的能力最强（AUC分别为0.80和0.79）。此外，浅层和深层毛细血管丛的全层图像以及中心凹周围VD均显示出至少中等的鉴别能力。我们发现视网膜微血管密度降低可能是诊断SCFP的潜在生物标志物。此外，SCFP患者的SFCT比对照组明显更薄。中心凹旁浅层VD和SFCT在区分SCFP患者和健康个体方面具有最高潜力。SCFP可能与视网膜和脉络膜小血管异常有关。然而，需要进一步研究来证实这种关联，并控制糖尿病和高血压的潜在混杂效应。
