Blandino Giovanni, Satchi-Fainaro Ronit, Tinhofer Ingeborg, Tonon Giovanni, Heilshorn Sarah C, Kwon Yong-Jun, Pestana Ana, Frascolla Carlotta, Pompili Luca, Puce Aurora, Iachettini Sara, Tocci Annalisa, Karkampouna Sofia, Kruithof-de Julio Marianna, Tocci Piera, Porciello Nicla, Maccaroni Klizia, Rutigliano Daniela, Shen Xiling, Ciliberto Gennaro
Translational Research Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Deapartment of Physiology and Pharmacology, Tel Aviv University, Tel Aviv, Israel.
J Exp Clin Cancer Res. 2024 Dec 28;43(1):334. doi: 10.1186/s13046-024-03258-7.
On September 23-24 (2024) the 6th Workshop IRE on Translational Oncology, titled "Cancer Organoids as Reliable Disease Models to Drive Clinical Development of Novel Therapies," took place at the IRCCS Regina Elena Cancer Institute in Rome. This prominent international conference focused on tumor organoids, bringing together leading experts from around the world.A central challenge in precision oncology is modeling the dynamic tumor ecosystem, which encompasses numerous elements that evolve spatially and temporally. Patient-derived 3D culture models, including organoids, explants, and engineered or bioprinted systems, have recently emerged as sophisticated tools capable of capturing the complexity and diversity of cancer cells interacting within their microenvironments. These models address critical unmet needs in precision medicine, particularly in aiding clinical decision-making. The rapid development of these human tissue avatars has enabled advanced modeling of cellular alterations in disease states and the screening of compounds to uncover novel therapeutic pathways.Throughout the event, distinguished speakers shared their expertise and research findings, illustrating how organoids are transforming our understanding of treatment resistance, metastatic dynamics, and the interaction between tumors and the surrounding microenvironment.This conference served as a pivotal opportunity to strengthen international collaborations and spark innovative translational approaches. Its goal was to accelerate the shift from preclinical research to clinical application, paving the way for increasingly personalized and effective cancer therapies.
2024年9月23日至24日，第六届转化肿瘤学IRE研讨会在罗马的 Regina Elena癌症研究机构举行，研讨会主题为“癌症类器官作为推动新型疗法临床开发的可靠疾病模型”。这次重要的国际会议聚焦于肿瘤类器官，汇聚了来自世界各地的顶尖专家。精准肿瘤学的一个核心挑战是对动态肿瘤生态系统进行建模，该系统包含许多在空间和时间上不断演变的要素。包括类器官、外植体以及工程化或生物打印系统在内的患者来源的3D培养模型，最近已成为能够捕捉癌细胞在其微环境中相互作用的复杂性和多样性的精密工具。这些模型满足了精准医学中关键的未满足需求，特别是在辅助临床决策方面。这些人体组织模型的快速发展使得能够对疾病状态下的细胞改变进行高级建模，并对化合物进行筛选以发现新的治疗途径。在整个活动中，杰出的演讲者分享了他们的专业知识和研究成果，阐述了类器官如何改变我们对治疗抗性、转移动力学以及肿瘤与周围微环境之间相互作用的理解。本次会议是加强国际合作并激发创新转化方法的关键契机。其目标是加速从临床前研究向临床应用的转变，为日益个性化和有效的癌症治疗铺平道路。
