Alazazi E A, Roslan A, Aziz F M A, Vanoh D, Seeni A, Ahmed S, Munir S, Mohammad J I, Murtey M D
Universiti Sains Malaysia, School of Dental Sciences, Health Campus, Kubang Kerian, Kelantan, Malaysia.
Universiti Sains Malaysia, School of Health Sciences, Health Campus, Kubang Kerian, Kelantan, Malaysia.
Malays J Pathol. 2024 Dec;46(3):355-368.
Oral cancer is considered the sixth most common form of cancer worldwide. It causes significant morbidity and mortality, especially in low socioeconomic status groups. However, Cancer chemoprevention encompasses the use of specific compounds to suppress the growth of tumours or inhibit carcinogenesis. Natural products have been identified as one of the most significant sources of anti-cancer agents. Meanwhile, several synthetic drugs exhibit potential cytotoxicity and can induce a wide range of degenerative diseases.
This review aims to determine the various plants, vegetables, and fruits possessing natural chemotherapeutic agents against oral cancer cells.
A comprehensive review of findings reported in articles retrieved from searches of computerised databases, hand searches, and authoritative texts. Inclusion databases include PubMed, Medline, Web of Science, Scopus, and Scientific. Exclusion Computerised databases: Wikipedia or unknown sources.
Natural products have fewer side effects, high selectivity, low toxicity, and eliminate cancer cells. Thus, the application of natural products as alternative oral and other cancer therapies has recently demonstrated remarkable progress.
Natural products have been widely used in developing oral anti-cancer drugs. Most of these natural products present bioactive chemical agents and novel mechanisms of action, such as the inhibition of tumour cell growth, the induction of apoptosis, DNA damage, and the inhibition of topoisomerases I and II. In future, the successful integration of natural products in oral cancer chemoprevention field depends on the advancement of molecular targeting, personalised approaches, and the exploration of novel drug delivery systems. Furthermore, integration of preclinical findings in clinical trials will be important for translating research into impactful interventions.
口腔癌被认为是全球第六大常见癌症形式。它会导致严重的发病率和死亡率，尤其是在社会经济地位较低的群体中。然而，癌症化学预防包括使用特定化合物来抑制肿瘤生长或抑制致癌作用。天然产物已被确定为抗癌药物的最重要来源之一。同时，几种合成药物具有潜在的细胞毒性，并可诱发多种退行性疾病。
本综述旨在确定具有针对口腔癌细胞的天然化学治疗剂的各种植物、蔬菜和水果。
对通过计算机数据库检索、手工检索和权威文献检索获得的文章中报道的研究结果进行全面综述。纳入数据库包括PubMed、Medline、科学引文索引、Scopus和Scientific。排除计算机数据库：维基百科或来源不明的文献。
天然产物副作用较少、选择性高、毒性低，且能消除癌细胞。因此，将天然产物用作口腔癌和其他癌症的替代疗法最近已取得显著进展。
天然产物已广泛应用于口腔抗癌药物的研发。这些天然产物大多具有生物活性化学剂和新的作用机制，如抑制肿瘤细胞生长、诱导细胞凋亡、DNA损伤以及抑制拓扑异构酶I和II。未来，天然产物在口腔癌化学预防领域的成功整合取决于分子靶向、个性化方法的进步以及新型药物递送系统的探索。此外，将临床前研究结果整合到临床试验中对于将研究转化为有影响力的干预措施至关重要。
