Steinke Jonathan, Di Cristanziano Veronica, Naendrup Jan-Hendrik, Cadar Dániel, Gabriel Martin, Grosser Roger, Sieg Noëlle, Altenrath Lisa, Welters Jesko, Simonis Alexander, Sprute Rosanne, Garcia Borrega Jorge, Steger Gertrud, Schmidt-Chanasit Jonas, Shimabukuro-Vornhagen Alexander, Gruell Henning
Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Eur J Clin Microbiol Infect Dis. 2025 Mar;44(3):747-752. doi: 10.1007/s10096-024-05021-4. Epub 2024 Dec 28.
Dengue is an increasing threat to individuals living in or visiting endemic countries. Effective vaccines have become available, but their use in travelers is typically only recommended to individuals with documented prior infection. We present a fatal case of severe dengue in an unvaccinated traveler without known prior dengue virus infection but longitudinal serologic and molecular evidence for secondary infection. In the context of this case and vaccination guidance for travelers, we discuss pre-vaccination screening, potential implications for travelers to regions with ongoing outbreaks, and emphasize the importance of serostatus-independent vaccines.
登革热对生活在或前往流行国家的个人构成日益严重的威胁。有效的疫苗已经问世，但通常仅建议有既往感染记录的旅行者使用。我们报告了一例未接种疫苗的旅行者发生严重登革热死亡病例，该旅行者既往无已知的登革热病毒感染，但有二次感染的纵向血清学和分子证据。结合该病例及旅行者疫苗接种指南，我们讨论了接种前筛查、对前往正在爆发疫情地区的旅行者的潜在影响，并强调了不依赖血清状态的疫苗的重要性。
