Hao Yuhan, Zeng Zexian, Yuan Minhang, Li Hui, Guo Shisong, Yang Yu, Jiang Shushu, Hawara Eva, Li Jianxu, Zhang Peng, Wang Jiawei, Xin Xiufang, Ma Wenbo, Liu Hongtao
CAS Center for Excellence in Molecular Plant Sciences (CEMPS), Institute of Plant Physiology and Ecology (SIPPE), Chinese Academy of Sciences, Shanghai 200031, People's Republic of China; School of Life Sciences, East China Normal University, Shanghai 200241, People's Republic of China.
CAS Center for Excellence in Molecular Plant Sciences (CEMPS), Institute of Plant Physiology and Ecology (SIPPE), Chinese Academy of Sciences, Shanghai 200031, People's Republic of China; Shanghai College of Life Science, University of Chinese Academy of Sciences, Shanghai 200031, People's Republic of China; College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, People's Republic of China.
Cell Host Microbe. 2025 Jan 8;33(1):137-150.e6. doi: 10.1016/j.chom.2024.12.003. Epub 2024 Dec 27.
Plant stomata open in response to blue light, allowing gas exchange and water transpiration. However, open stomata are potential entry points for pathogens. Whether plants can sense pathogens and mount defense responses upon stomatal opening and how blue-light cues are integrated to balance growth-defense trade-offs are poorly characterized. We show that the Arabidopsis blue-light photoreceptor CRYPTOCHROME 1 (CRY1) mediates various aspects of immunity, including pathogen-triggered stomatal closure as well as activation of plant immunity through a typical light-responsive protein LATE UPREGULATED IN RESPONSE TO HYALOPERONOSPORA PARASITICA (LURP1). LURP1 undergoes N-terminal palmitoylation in the presence of bacterial flagellin, prompting a change in subcellular localization from the cytoplasm to plasma membrane, where it enhances the activity of the receptor FLAGELLIN SENSING 2 (FLS2) to mediate plant defense. Collectively, these findings reveal that blue light regulates stomatal defense and highlight the dual functions of CRY1 in photosynthesis and immunity.
植物气孔会对蓝光做出反应而张开，从而实现气体交换和水分蒸腾。然而，开放的气孔是病原体潜在的入侵点。植物是否能够在气孔张开时感知病原体并启动防御反应，以及蓝光信号如何整合以平衡生长与防御之间的权衡，目前还知之甚少。我们发现拟南芥蓝光受体隐花色素1（CRY1）介导免疫的各个方面，包括病原体触发的气孔关闭以及通过一种典型的光响应蛋白——响应寄生霜霉病上调的晚期蛋白（LURP1）激活植物免疫。在细菌鞭毛蛋白存在的情况下，LURP1的N端会发生棕榈酰化，促使其亚细胞定位从细胞质转变为质膜，在质膜上它增强了受体鞭毛蛋白感应2（FLS2）的活性以介导植物防御。总的来说，这些发现揭示了蓝光调节气孔防御，并突出了CRY1在光合作用和免疫中的双重功能。
