Zhao Yiping, Zhao Fanyu, Liu Qian, Liu Li, Wang Fang, Hu Xiuying
Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, and West China School of Nursing, Sichuan University, PO Box No.37, Guo Xue Street, Chengdu, 610041, Sichuan, PR China.
Sci Rep. 2024 Dec 28;14(1):31177. doi: 10.1038/s41598-024-82346-2.
The trend of the aging population worldwide is becoming increasingly severe. As people age, constipation becomes increasingly common in older adults, causing varying degrees of physical and psychological harm to them. Dietary intervention is a common nonpharmacological therapy. Resistant starch is a type of dietary fiber that can regulate the gut microbiota and alleviate chronic constipation. However, few studies have explored the effects of different types of rice on chronic constipation in older adults. This protocol aims to evaluate the effects of rice with different contents of resistant starch on chronic constipation in old adults. This trial is a double-blind, two-arm randomized controlled trial. Older adults with chronic constipation residing in long-term care facilities will be recruited. Participants will be randomly assigned to receive A rice (resistant starch: 11-20%) or receive B rice (resistant starch: 0.1-0.5%). Both groups will adopt the serving of individual dishes, and the nutrition experts calculated the consumption of rice in the two groups according to the different conditions of each older person to ensure that the number of calories in the meal remained unchanged and that the other dietary components remained unchanged. The intervention will last for a total of 24 weeks. Participants will undergo follow-up via questionnaires at 6, 12, and 24 weeks during the intervention. The primary outcome will be constipation symptoms assessed by the Wexner questionnaire. The secondary outcomes will be quality of life, depression, anxiety and sleep quality. This is the first randomized controlled trial on the effects of rice with different contents of resistant starch on chronic constipation in older adults. It is expected that this study, if proven effective in relieving constipation symptoms in older adults, will provide evidence-based constipation care for medical staff.Trial registration number: retrospectively registered on Chinese Clinical Trial Registry.
全球人口老龄化趋势日益严峻。随着人们年龄的增长，便秘在老年人中越来越普遍，给他们带来了不同程度的身心伤害。饮食干预是一种常见的非药物疗法。抗性淀粉是一种膳食纤维，可调节肠道微生物群并缓解慢性便秘。然而，很少有研究探讨不同类型的大米对老年人慢性便秘的影响。本方案旨在评估不同抗性淀粉含量的大米对老年人慢性便秘的影响。本试验是一项双盲、双臂随机对照试验。将招募居住在长期护理机构中的慢性便秘老年人。参与者将被随机分配接受A米（抗性淀粉：11-20%）或接受B米（抗性淀粉：0.1-0.5%）。两组均采用分餐制，营养专家根据每位老年人的不同情况计算两组大米的摄入量，以确保每餐的热量不变，其他饮食成分不变。干预将持续24周。在干预期间，参与者将在第6、12和24周通过问卷调查进行随访。主要结局将是通过Wexner问卷评估的便秘症状。次要结局将是生活质量、抑郁、焦虑和睡眠质量。这是第一项关于不同抗性淀粉含量的大米对老年人慢性便秘影响的随机对照试验。预计本研究如果被证明对缓解老年人便秘症状有效，将为医护人员提供循证便秘护理。试验注册号：在中国临床试验注册中心进行回顾性注册。
