Hazrati-Raziabad Reza, Aslani Ramin, Shariatifar Nabi, Arabameri Majid, Sadighara Parisa, Khaniki Gholamreza Jahed
Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.
Sci Rep. 2024 Dec 28;14(1):31305. doi: 10.1038/s41598-024-82758-0.
Bisphenol A (BPA) is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics, which has risks for human health. This study aimed to investigate BPA contents in canned fruit and vegetable samples using Gas Chromatography-Mass Spectrometry (GC-MS). Furthermore, health risks were assessed for Iranian adults and children using Monte Carlo simulations. The mean concentration of BPA in canned samples of lentils, apricots, cherries, pineapples, eggplant stew, and green peas was 21.87, 4.52, 3.92, 1.86, 1.67 and 1.62 µg/kg, respectively. The level of BPA in the samples was within the standard level. The pH value in canned fruits varied from 3.6 to 4.7 (mean = 4.15) and in canned vegetables from 4.3 to 5.9 (mean = 5.21). The mean sugar content was 41.42% (ranged 38-48%), and the mean fat value was 24.234% (ranged 24.7-48%). The 95th percentile EDI values of BPA in canned fruit for adults and children were 6.12E-08, and 2.16E-07 mg/kg bw/day; and in canned vegetables were 1.78E-07, and 6.26E-07 mg/kg bw/day, respectively. The 95th percentile THQ values in canned fruit for adults and children were 1.48E-06 and 5.24E-06, and in canned vegetables were 3.56E-06 and 1.27E-05, respectively, and HQ was less than 1. According to the obtained results, it can be concluded that the contents of BPA in canned fruits and vegetables do not pose a safety concern for consumers in Iran.
双酚A（BPA）是一种大量生产的化学物质，主要用于聚碳酸酯塑料的生产，对人体健康存在风险。本研究旨在使用气相色谱-质谱联用仪（GC-MS）调查罐装水果和蔬菜样品中的双酚A含量。此外，还使用蒙特卡洛模拟评估了伊朗成年人和儿童面临的健康风险。小扁豆、杏子、樱桃、菠萝、茄子炖菜和青豆罐装样品中双酚A的平均浓度分别为21.87、4.52、3.92、1.86、1.67和1.62微克/千克。样品中双酚A的含量在标准水平以内。罐装水果的pH值在3.6至4.7之间（平均值 = 4.15），罐装蔬菜的pH值在4.3至5.9之间（平均值 = 5.21）。平均含糖量为41.42%（范围为38 - 48%），平均脂肪含量为24.234%（范围为24.7 - 48%）。罐装水果中双酚A对成年人和儿童的第95百分位数估计每日摄入量（EDI）值分别为6.12×10⁻⁸和2.16×10⁻⁷毫克/千克体重/天；罐装蔬菜中分别为1.78×10⁻⁷和6.26×10⁻⁷毫克/千克体重/天。罐装水果中成年人和儿童的第95百分位数危害商（THQ）值分别为1.48×10⁻⁶和5.24×10⁻⁶，罐装蔬菜中分别为3.56×10⁻⁶和1.27×10⁻⁵，且危害商小于1。根据所得结果，可以得出结论，伊朗罐装水果和蔬菜中的双酚A含量对消费者不构成安全问题。
