Wang Tongtong, Wang Hui, Zhang Zhen-Yu, Chang Tian-Zhi, Yu Ying-Tan, Miao Da-Shuai, Zhang Bing-Jie, Qiu Wu-Xian, Zhang Chen-Yang, Tong Xiao
Affiliated Hospital of Jiangnan University, Wuxi, 214000, Jiangsu, China.
Wuxi Medical College, Jiangnan University, Wuxi, 214122, Jiangsu, China.
Sci Rep. 2024 Dec 28;14(1):31482. doi: 10.1038/s41598-024-83079-y.
Vitamin D is crucial for maintaining bone health and development, and bone mineral accumulation during childhood and adolescence affects long-term bone health. Vitamin D deficiency has been widely recognized as one of the main causes of osteoporosis and fractures, especially during the growth and development stage of children. Recent studies have shown that vitamin D deficiency may affect the deviation of bone development in children by mediating lipid metabolism disorders, but its specific mechanism of action has not been fully elucidated. In this study, through clinical correlation analysis, it was found that vitamin D deficiency was negatively correlated with lipid metabolism levels. Subsequently, lipidomic analysis of vitamin D-deficient mice and children showed that triglycerides were the main lipid metabolites. It was found that the triglyceride synthesis pathway plays a key role in bone development in vitamin D-deficient obese children. Our study found that vitamin D deficiency mediates bone dysplasia by affecting triglyceride synthesis. These findings provide new insights into the mechanisms by which vitamin D deficiency affects bone development in children, which may guide more precise clinical interventions and support the development of new clinical treatments.
维生素D对维持骨骼健康和发育至关重要，儿童和青少年时期的骨矿物质积累会影响长期骨骼健康。维生素D缺乏已被广泛认为是骨质疏松症和骨折的主要原因之一，尤其是在儿童生长发育阶段。最近的研究表明，维生素D缺乏可能通过介导脂质代谢紊乱影响儿童骨骼发育的偏差，但其具体作用机制尚未完全阐明。在本研究中，通过临床相关性分析发现，维生素D缺乏与脂质代谢水平呈负相关。随后，对维生素D缺乏小鼠和儿童进行脂质组学分析表明，甘油三酯是主要的脂质代谢产物。研究发现，甘油三酯合成途径在维生素D缺乏的肥胖儿童骨骼发育中起关键作用。我们的研究发现，维生素D缺乏通过影响甘油三酯合成介导骨骼发育异常。这些发现为维生素D缺乏影响儿童骨骼发育的机制提供了新的见解，这可能指导更精确的临床干预，并支持新的临床治疗方法的开发。
