Isles A F, Newth C J
J Allergy Clin Immunol. 1985 Mar;75(3):377-81. doi: 10.1016/0091-6749(85)90075-2.
Sustained-release theophylline formulations should be most useful in young children who have rapid clearance and long sleep intervals. Somophyllin-12 is a recently introduced, newly designed, bead-filled capsule. We tested its ability to provide adequate serum concentrations at steady state in 16 children ages 0.9 to 5.1 yr. On a 12 hourly dosing schedule, mean dose was 25.9 mg/kg per day, and mean fluctuation was 138%. Seven children (43.8%) had fluctuations less than 100%, whereas four children (25%) had fluctuations more than 200%. Six patients with excessive fluctuation (greater than 100%) were restudied on an eight hourly dosing schedule. Mean dose was 28.7 mg/kg per day, and fluctuation was 59%. Because of the excessive fluctuation (greater than 100%) experienced by half these young children, therapy with this product should be initiated with an eight hourly dosing schedule. However, when dose and dosing interval are subsequently individualized, many young children can be switched to twice daily dosing with its improved compliance and convenience.
缓释型茶碱制剂对清除速度快且睡眠时间长的幼儿最为有用。Somophyllin - 12是一种最近推出的、新设计的、填充小珠的胶囊。我们测试了其在16名年龄在0.9至5.1岁儿童中达到稳态时提供足够血清浓度的能力。按照每12小时一次的给药方案，平均剂量为每天25.9毫克/千克，平均波动为138%。7名儿童（43.8%）的波动小于100%，而4名儿童（25%）的波动大于200%。对6名波动过大（大于100%）的患者按照每8小时一次的给药方案重新进行了研究。平均剂量为每天28.7毫克/千克，波动为59%。由于这些幼儿中有一半出现了过大波动（大于100%），因此使用该产品进行治疗时应从每8小时一次的给药方案开始。然而，当随后对剂量和给药间隔进行个体化调整时，许多幼儿可以改为每日两次给药，这样能提高依从性并更方便。
