Welch M J, Kemp J P, Orgel H A, Meltzer E O
J Asthma. 1985;22(5):249-52. doi: 10.3109/02770908509077455.
We studied the absorption properties of a new sustained-release theophylline, Theo-Dur Sprinkle (TS), to see if this formulation when given on a b.i.d. basis results in acceptable steady-state theophylline levels in children with asthma. Twelve patients (ages 5-8 years), after multiple TS dosing, had serum theophylline levels determined over a 10-hr period after a morning TS dose. Fluctuations in serum theophylline concentrations were acceptable with the observed mean percent peak-to-trough fluctuation [(peak-trough/trough) x 100] being 53%. Patients required higher than usually recommended theophylline doses to obtain therapeutic levels, suggesting incomplete absorption of TS; this was documented with one patient using a 100% bioavailable theophylline product as a comparison.
我们研究了一种新型缓释茶碱Theo-Dur Sprinkle（TS）的吸收特性，以确定这种每日两次给药的剂型能否使哮喘儿童的茶碱水平达到可接受的稳态。12名年龄在5至8岁的患者在多次服用TS后，于早晨服用TS剂量后的10小时内测定血清茶碱水平。血清茶碱浓度的波动是可接受的，观察到的平均峰谷波动百分比[（峰浓度-谷浓度）/谷浓度×100]为53%。患者需要高于通常推荐的茶碱剂量才能达到治疗水平，这表明TS吸收不完全；一名患者使用100%生物利用度的茶碱产品作为对照记录了这一点。
