Rabeeh V P Muhammad, Hanas T
Nanomaterials Research Laboratory, School of Materials Science and Engineering, National Institute of Technology Calicut, Kozhikode, 673601, India.
Department of Mechanical Engineering, National Institute of Technology Calicut, Kozhikode, 673601, India.
Prog Biomater. 2022 Jun;11(2):163-191. doi: 10.1007/s40204-022-00189-4. Epub 2022 May 18.
Biodegradable metals have gained vast attention as befitting candidates for developing degradable metallic implants. Such implants are primarily employed for temporary applications and are expected to degrade or resorbed after the tissue is healed. Fe-based materials have generated considerable interest as one of the possible biodegradable metals. Like other biometals such as Mg and Zn, Fe exhibits good biocompatibility and biodegradability. The versatility in the mechanical behaviour of Fe-based materials makes them a better choice for load-bearing applications. However, the very low degradation rate of Fe in the physiological environment needs to be improved to make it compatible with tissue growth. Several studies on tailoring the degradation behaviour of Fe in the human body are already reported. Majority of these works include studies on the effect of manufacturing and processing techniques on biocompatibility and biodegradability. This article focuses on a comprehensive review and analysis of the various manufacturing and processing techniques so far reported for developing biodegradable iron-based orthopaedic implants. The current status of research in the field is neatly presented, and a summary of the works is included in the article for the benefit of researchers in the field to contextualise their research and effectively find the lacunae in the existing scholarship.
可生物降解金属作为开发可降解金属植入物的合适候选材料已受到广泛关注。此类植入物主要用于临时应用，预计在组织愈合后会降解或吸收。铁基材料作为可能的可生物降解金属之一已引起了相当大的兴趣。与其他生物金属如镁和锌一样，铁具有良好的生物相容性和生物降解性。铁基材料力学行为的多样性使其成为承重应用的更好选择。然而，铁在生理环境中的极低降解速率需要提高，以使其与组织生长相兼容。已经报道了几项关于调整铁在人体中降解行为的研究。这些工作大多包括研究制造和加工技术对生物相容性和生物降解性的影响。本文重点对迄今为止报道的用于开发可生物降解铁基骨科植入物的各种制造和加工技术进行全面综述和分析。该领域的研究现状得到了清晰呈现，文章还包含了相关工作的总结，以帮助该领域的研究人员将他们的研究置于背景之中，并有效地找出现有学术研究中的空白。
