Lambertucci Sébastien, Deakin Faye
Analytik Jena AG Analytik Jena UK Ltd London UK.
Eng Biol. 2024 Dec 23;8(4):69-73. doi: 10.1049/enb2.12036. eCollection 2024 Dec.
Breakthroughs in engineering biology will solve the challenges facing humanity, by harnessing life itself. Standing in the way of these breakthroughs are the technical challenges of collecting the requisite data. Data variability and reproducibility problems, mean the odds are stacked against emerging biotechs. Automation has long been known to solve both problems; Let a robot do the pipetting and get reproducible data with less hands-on time. Although transitioning to automation has clear benefits, it can introduce additional complexity if done incorrectly. Analytik Jena UK has focused on supporting this transition to automation. We have found the combining of industry expertise with the biology know-how at the bench is paramount. Great automation should empower the scientist. Scientists should be trained on how to harness their automation. Through industry-customer relationships, we have successfully automated platforms for building DNA to antibody development. Through this partnership, we can enable a smooth translation of engineering biology to scalable industrial solutions. In this communication we have highlighted some successful examples where translating engineering biology workflows onto automation has proven beneficial, paving the way to industry ready solutions.
工程生物学的突破将通过利用生命本身来解决人类面临的挑战。而收集必要数据的技术挑战阻碍了这些突破。数据变异性和可重复性问题意味着新兴生物技术公司面临不利局面。长期以来，人们都知道自动化可以解决这两个问题；让机器人进行移液操作，就能在减少人工操作时间的情况下获得可重复的数据。虽然向自动化过渡有明显的好处，但如果操作不当，可能会引入额外的复杂性。英国耶拿分析仪器公司专注于支持向自动化的这种过渡。我们发现，将行业专业知识与实验室的生物学知识相结合至关重要。出色的自动化应该赋能科学家。科学家应该接受如何利用自动化的培训。通过与行业客户的合作关系，我们成功地将从构建DNA到抗体开发的平台自动化。通过这种合作关系，我们可以实现工程生物学向可扩展工业解决方案的顺利转化。在本交流中，我们重点介绍了一些成功案例，其中将工程生物学工作流程转化为自动化已证明是有益的，为实现行业就绪的解决方案铺平了道路。
