印度人群中用于筛查糖尿病前期的糖尿病前期风险测试的外部验证
External validation of Prediabetes Risk Test in Indian population for screening prediabetes.
作者信息
Aditya Jadhav Radhika, Arun Maiya G, Umakanth Shashikiran, Shivashankara K N
机构信息
PhD Scholar, Centre for Diabetic Foot Care & Research (Physiotherapy), Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Dean & Professor, Centre for Diabetic Foot Care & Research (Physiotherapy), Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India.
出版信息
Med J Armed Forces India. 2024 Dec;80(Suppl 1):S107-S112. doi: 10.1016/j.mjafi.2022.11.001. Epub 2023 Jan 4.
BACKGROUND
Prediabetes Risk Test (PRT) has been found valid in the Western population for screening prediabetes. However, ethnicity, race, geographical and other biological characteristics have been linked to the development of prediabetes. There is a dearth of literature on the external validity of PRT in the Indian population. So, the objective of this study was to assess the external validity of the PRT in the Indian population for screening prediabetes.
METHODS
The study contained 522 participants aged between 18 and 60 years. The medical history, physical activity level and anthropometric measures were assessed. Prediabetes was diagnosed using fasting blood sugar and HbA levels. External validation of PRT was performed using specificity, sensitivity, positive predictive value, negative predictive value, positive likelihood ratio and negative likelihood ratio. The receiver operating curve was plotted to identify the optimum cut-off value for Indians.
RESULTS
The study found that the sensitivity of PRT was 48.1%, specificity 95.5%, positive predictive value 66.1% and negative predictive value 90.9% for screening prediabetes in the Indian population. Receiver operating curve analysis revealed that the optimum cut-off of PRT was around 3 for Indians.
CONCLUSION
The results showed that PRT might not be useful in the Indian population to identify the true positives of prediabetes as it has a sensitivity of 48.1%. However, it can be helpful to identify the true negatives as the specificity is 95.5%. Further study is required to modify PRT for the Indian context to make it more appropriate for the Indian population.
背景
已发现糖尿病前期风险测试（PRT）在西方人群中对筛查糖尿病前期有效。然而，种族、地理及其他生物学特征与糖尿病前期的发生有关。关于PRT在印度人群中的外部有效性的文献较少。因此，本研究的目的是评估PRT在印度人群中筛查糖尿病前期的外部有效性。
方法
该研究纳入了522名年龄在18至60岁之间的参与者。评估了他们的病史、身体活动水平和人体测量指标。使用空腹血糖和糖化血红蛋白（HbA）水平诊断糖尿病前期。通过特异性、敏感性、阳性预测值、阴性预测值、阳性似然比和阴性似然比来进行PRT的外部验证。绘制受试者工作特征曲线以确定印度人的最佳截断值。
结果
研究发现，在印度人群中筛查糖尿病前期时，PRT的敏感性为48.1%，特异性为95.5%，阳性预测值为66.1%，阴性预测值为90.9%。受试者工作特征曲线分析显示，印度人的PRT最佳截断值约为3。
结论
结果表明，PRT在印度人群中识别糖尿病前期真正阳性病例可能没有用，因为其敏感性为48.1%。然而，由于其特异性为95.5%，它有助于识别真正的阴性病例。需要进一步研究对PRT进行调整，使其更适合印度人群的情况。
Zotero 插件