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合并糖尿病、高血压急症及过量饮酒的鼻眶脑型毛霉菌病的诊断挑战

Diagnostic Challenges in Rhino-Orbito-Cerebral Mucormycosis With Diabetes Mellitus, Hypertensive Emergency, and Excess Alcohol Consumption.

作者信息

Mohsin Moaz, Owasoyo Oluwaseyi, Rahim Hafiz Muhammad Zahid, Rahim Uzma, Rahim Asma, Kinnera Swaroopa, Sunil Kashish Keswani, Awan Abrar A, Hassan Ayesha, Munir Shahzaib

机构信息

Acute Medicine, Royal Stoke University Hospital, Stoke-on-Trent, GBR.

Stroke, Queens Hospital Center, Romford, GBR.

出版信息

Cureus. 2024 Nov 28;16(11):e74663. doi: 10.7759/cureus.74663. eCollection 2024 Nov.

Abstract

A 72-year-old male with a history of excessive alcohol intake (35+ units of alcohol daily) presented to the emergency department with bilateral vision loss, periorbital swelling, headache, and sinus congestion with bloody nasal discharge. He was newly diagnosed with diabetes mellitus and presented with severe diabetic ketoacidosis and a hypertensive emergency (blood pressure of 240/90 mmHg). Despite initial normal brain and orbital imaging, the clinical presentation was complicated by multiple life-threatening conditions and a prior immunocompetent status, thereby delaying the early suspicion of mucormycosis. This case underlines the diagnostic challenges in managing mucormycosis in a previously immunocompetent patient with overlapping critical conditions.

摘要

一名72岁男性,有过量饮酒史(每日饮酒35个单位以上),因双眼视力丧失、眶周肿胀、头痛、鼻窦充血伴血性鼻涕而就诊于急诊科。他新诊断为糖尿病,并发严重糖尿病酮症酸中毒和高血压急症(血压240/90 mmHg)。尽管最初脑部和眼眶影像学检查正常,但临床表现因多种危及生命的情况和既往免疫功能正常状态而变得复杂,从而延误了对毛霉菌病的早期怀疑。该病例突显了在管理一名先前免疫功能正常但合并多种危急情况的患者时诊断毛霉菌病所面临的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a15/11681835/44271a1f9a0c/cureus-0016-00000074663-i01.jpg

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