聚焦超声联合免疫疗法在动物实体瘤模型中的远隔效应：一项系统评价与荟萃分析
Abscopal effect of focused ultrasound combined immunotherapy in animal solid tumor model: a systematic reviews and meta-analysis.
作者信息
Hu Chao, Li Hui, Deng Tao, Liu Zheng, Yang Li, Peng Li, Jiang Ming Yan, Chen Wen Zhi
机构信息
State Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing, China.
Department of Pulmonary and Critical Medicine, Xiangtan Central Hospital, Xiangtan, China.
出版信息
Front Immunol. 2024 Dec 13;15:1474343. doi: 10.3389/fimmu.2024.1474343. eCollection 2024.
INTRODUCTION
The abscopal effect, a systemic anti-tumor response triggered by localized treatment, has gained attention but remains poorly understood. This study evaluates the efficacy and consistency of focused ultrasound (FUS) combined with immunotherapy in inducing the abscopal effect.
METHODS
A systematic review and meta-analysis were conducted on preclinical studies using solid tumor models. Data on tumor response, immune modulation, and survival outcomes were analyzed to assess the combination therapy's effectiveness.
RESULTS
FUS combined with immunotherapy enhanced anti-tumor responses at local and distant sites, with evidence of immune activation and increased abscopal effect rates. However, heterogeneity across tumor models and protocols was observed.
DISCUSSION
The findings provide a theoretical basis for FUS-immunotherapy combinations in cancer treatment, while emphasizing the need for standardized protocols and further research to elucidate underlying mechanisms.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/prospero/, identifier CRD42023460710.
引言
远隔效应是一种由局部治疗引发的全身性抗肿瘤反应，已受到关注，但仍了解不足。本研究评估聚焦超声（FUS）联合免疫疗法诱导远隔效应的疗效和一致性。
方法
对使用实体瘤模型的临床前研究进行系统评价和荟萃分析。分析肿瘤反应、免疫调节和生存结果的数据，以评估联合疗法的有效性。
结果
FUS联合免疫疗法增强了局部和远处部位的抗肿瘤反应，有免疫激活和远隔效应率增加的证据。然而，观察到肿瘤模型和方案之间存在异质性。
讨论
这些发现为癌症治疗中FUS-免疫疗法联合应用提供了理论基础，同时强调需要标准化方案并进一步研究以阐明潜在机制。
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