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Angiotensin-converting enzyme 2 modulation of pyroptosis pathway in traumatic brain injury: A potential therapeutic target.

作者信息

Guo Jinxiu, Zhao Shiyuan, Chu Xue, Wang Changshui, Meng Junjun, Wei Shanshan, Wang Jianhua, Guo Yujin, Kong Weihua, Sun Wenxue, Zhang Tao, Dang Ruili, Yang Mengqi, Chen Jing, Jiang Pei

机构信息

Institute of Clinical Pharmacy, Jining First People's Hospital, Shandong First Medical University, Jining, P.R. China.

Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, P.R. China.

出版信息

Clin Transl Med. 2025 Jan;15(1):e70167. doi: 10.1002/ctm2.70167.

DOI:10.1002/ctm2.70167
PMID:39737729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11686427/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c535/11686427/4b1af90a9182/CTM2-15-e70167-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c535/11686427/acbfe43b788c/CTM2-15-e70167-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c535/11686427/4b490bdf7b09/CTM2-15-e70167-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c535/11686427/29d97c7b2fac/CTM2-15-e70167-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c535/11686427/4b1af90a9182/CTM2-15-e70167-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c535/11686427/acbfe43b788c/CTM2-15-e70167-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c535/11686427/4b490bdf7b09/CTM2-15-e70167-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c535/11686427/29d97c7b2fac/CTM2-15-e70167-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c535/11686427/4b1af90a9182/CTM2-15-e70167-g002.jpg

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本文引用的文献

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STING mediates neuroinflammatory response by activating NLRP3-related pyroptosis in severe traumatic brain injury.STING 通过激活 NLRP3 相关细胞焦亡介导严重创伤性脑损伤的神经炎症反应。
J Neurochem. 2022 Sep;162(5):444-462. doi: 10.1111/jnc.15678. Epub 2022 Aug 2.
2
Huc-MSCs-derived exosomes attenuate inflammatory pain by regulating microglia pyroptosis and autophagy via the miR-146a-5p/TRAF6 axis.人脐带间充质干细胞来源的外泌体通过 miR-146a-5p/TRAF6 轴调节小胶质细胞焦亡和自噬来减轻炎性疼痛。
J Nanobiotechnology. 2022 Jul 14;20(1):324. doi: 10.1186/s12951-022-01522-6.
3
Liraglutide attenuate central nervous inflammation and demyelination through AMPK and pyroptosis-related NLRP3 pathway.
利拉鲁肽通过 AMPK 和焦亡相关 NLRP3 通路减轻中枢神经系统炎症和脱髓鞘。
CNS Neurosci Ther. 2022 Mar;28(3):422-434. doi: 10.1111/cns.13791. Epub 2022 Jan 5.
4
Spike Proteins of SARS-CoV-2 Induce Pathological Changes in Molecular Delivery and Metabolic Function in the Brain Endothelial Cells.SARS-CoV-2 的刺突蛋白会引起脑神经内皮细胞中分子传递和代谢功能的病理性变化。
Viruses. 2021 Oct 8;13(10):2021. doi: 10.3390/v13102021.
5
Fiery Cell Death: Pyroptosis in the Central Nervous System.细胞焦亡：中枢神经系统中的细胞 pyroptosis。
Trends Neurosci. 2020 Jan;43(1):55-73. doi: 10.1016/j.tins.2019.11.005. Epub 2019 Dec 13.
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Thromb Haemost. 2020 Feb;120(2):329-343. doi: 10.1055/s-0039-3400304. Epub 2019 Nov 30.
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J Oncol. 2018 Nov 8;2018:6301980. doi: 10.1155/2018/6301980. eCollection 2018.
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Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases.花生四烯酸代谢产物与心血管和代谢疾病
Int J Mol Sci. 2018 Oct 23;19(11):3285. doi: 10.3390/ijms19113285.
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Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo.Caspase-1 的消融可防止体外和体内 TBI 诱导的细胞焦亡。
J Neuroinflammation. 2018 Feb 19;15(1):48. doi: 10.1186/s12974-018-1083-y.