Xu Shujuan, Wang Zihan, Guo Fan, Zhang Yehao, Peng Han, Zhang Huiyu, Liu Zixin, Cao Ce, Xin Gaojie, Chen Yuan Yuan, Fu Jianhua
Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Department of Oral Implantology, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, 110122, China.
Cell Death Dis. 2024 Dec 30;15(12):934. doi: 10.1038/s41419-024-07303-3.
The influence of the mitochondrial control system on ischemic heart disease has become a major focus of current research. Mitophagy, as a very crucial part of the mitochondrial control system, plays a special role in ischemic heart disease, unlike mitochondrial dynamics. The published reviews have not explored in detail the unique function of mitophagy in ischemic heart disease, therefore, the aim of this paper is to summarize how mitophagy regulates the progression of ischemic heart disease. We conclude that mitophagy affects ischemic heart disease by promoting cardiomyocyte hypertrophy and fibrosis, the progression of oxidative stress, the development of inflammation, and cardiomyocyte death, and that the specific mechanisms of mitophagy are worthy of further investigation.
线粒体控制系统对缺血性心脏病的影响已成为当前研究的主要焦点。与线粒体动力学不同，线粒体自噬作为线粒体控制系统的一个非常关键的部分，在缺血性心脏病中发挥着特殊作用。已发表的综述尚未详细探讨线粒体自噬在缺血性心脏病中的独特功能，因此，本文的目的是总结线粒体自噬如何调节缺血性心脏病的进展。我们得出结论，线粒体自噬通过促进心肌细胞肥大和纤维化、氧化应激的进展、炎症的发展以及心肌细胞死亡来影响缺血性心脏病，并且线粒体自噬的具体机制值得进一步研究。
