Cheung Yee Tak Derek, Mak Tin Shun Titan, Luk Tzu Tsun, Ching Kam-Wing Joe, Wong Nga-Ting Grace, Chan Ching Han Helen, Wang Man Ping, Lam Tai Hing
School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 5/F, Academic Building, 3 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Integrated Centre on Smoking Cessation, Tung Wah Group of Hospitals, 10/F, Tung Chiu Commercial Centre, 193-197 Lockhart Road, Wan Chai, Hong Kong SAR, China.
Sci Rep. 2024 Dec 30;14(1):31912. doi: 10.1038/s41598-024-83405-4.
Alcohol use attenuates successful smoking cessation. We examined the feasibility, acceptability, and preliminary efficacy of a brief alcohol intervention in smokers. In this two-arm, assessor-blinded randomized controlled trial, we randomized 100 daily smokers (82.0% male, mean age = 43.7 years) with past-year alcohol use in smoking cessation clinics. Both intervention (n = 51) and control (n = 49) groups received conventional smoking cessation treatment, the intervention group additionally received a brief alcohol intervention. Primary outcome was biochemically validated tobacco abstinence at 2 months. Secondary outcomes included Alcohol Use Disorders Identification Test (AUDIT) scores, self-reported past 7-day alcohol consumption in alcohol units, feasibility, and acceptability scores at 2 months. By intention-to-treat, the intervention group showed higher validated abstinence (11.8% vs. 10.2%, Risk Ratio = 1.15, 95%CI = 0.38-3.53), lower AUDIT score (5.3 vs. 6.5), and lower alcohol consumption (5.6 vs. 7.1) than the control group, but the differences were not significant. Overall, the feasibility was high (4.2/5.0), and the acceptability was modest (5.0/7.0). In all participants, reduction in smoking relapse risk due to alcohol use from baseline to 2-month follow-up was associated with higher biochemically validated abstinence (Adjusted odds ratio: 1.55, 95% CI = 1.05-2.28). Our brief alcohol intervention is feasible, acceptable, and potentially efficacious to promote tobacco abstinence and alcohol reduction.
饮酒会削弱成功戒烟的几率。我们研究了针对吸烟者的简短酒精干预措施的可行性、可接受性和初步疗效。在这项双臂、评估者盲法随机对照试验中，我们将100名每日吸烟且在过去一年中有饮酒行为的吸烟者（82.0%为男性，平均年龄 = 43.7岁）随机分配到戒烟诊所。干预组（n = 51）和对照组（n = 49）均接受常规戒烟治疗，干预组还额外接受了简短酒精干预。主要结局是在2个月时经生化验证的烟草戒断情况。次要结局包括酒精使用障碍识别测试（AUDIT）得分、自我报告的过去7天以酒精单位计算的饮酒量、2个月时的可行性和可接受性得分。按意向性分析，干预组的经验证戒断率更高（11.8%对10.2%，风险比 = 1.15，95%置信区间 = 0.38 - 3.53），AUDIT得分更低（5.3对6.5），酒精摄入量更低（5.6对7.1），但差异不显著。总体而言，可行性较高（4.2/5.0），可接受性一般（5.0/7.0）。在所有参与者中，从基线到2个月随访期间因饮酒导致的吸烟复发风险降低与经生化验证的更高戒断率相关（调整后的优势比：1.55，95%置信区间 = 1.05 - 2.28）。我们的简短酒精干预措施在促进戒烟和减少饮酒方面是可行、可接受且可能有效的。
