Yang Chenlu, Guo Dandan, Zhu Yugang, Tian Min, Zhang Bohan, Yang Yang, Yang Qingchao, Liu Yiming
Department of Neurology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Sci Rep. 2024 Dec 30;14(1):31966. doi: 10.1038/s41598-024-83567-1.
One of the most common post-COVID-19 condition is persistent fatigue, while post-COVID fatigue among Parkinson's disease (PD) patients is less known. This study was aimed to investigate the prevalence and risk factors of post-COVID fatigue in PD patients at 1 month and 12 months after symptom onset. PD patients attending clinic from December 2022 to January 2023 were enrolled consecutively in the study. All participants were assessed demographics, details of COVID-19 infection, clinical characteristics as well as fatigue status with Fatigue Severity Scale (FSS) (cutoff ≥ 36) at 1-month and 12-month after symptom onset. Univariate and multivariate Logistic regression analysis were used to evaluate the risk factors of post-COVID fatigue. Fatigue symptoms were reported by 75.89% of PD patients and associated with decreased physical activity and number of initial symptoms of COVID-19 at 1 month. Meanwhile, 32.99% of PD patients at 12 months reported persistent fatigue. Using of antiviral drugs, decreased physical activity, anxiety status and delayed ON were associated with persistent fatigue at 12 months. Clinically persistent fatigue was pervasive in our study at 12-month after COVID infection. These findings implicate using of antiviral drugs, decreased physical activity, anxiety status and delayed ON were possible predictors of post-COVID persistent fatigue.
新型冠状病毒肺炎（COVID-19）后最常见的状况之一是持续性疲劳，而帕金森病（PD）患者的COVID-19后疲劳情况鲜为人知。本研究旨在调查PD患者在症状出现后1个月和12个月时COVID-19后疲劳的患病率及危险因素。2022年12月至2023年1月到门诊就诊的PD患者连续纳入本研究。所有参与者在症状出现后1个月和12个月时接受人口统计学评估、COVID-19感染细节、临床特征以及使用疲劳严重程度量表（FSS）（临界值≥36）评估疲劳状态。采用单因素和多因素Logistic回归分析评估COVID-19后疲劳的危险因素。75.89%的PD患者报告有疲劳症状，且在1个月时与身体活动减少及COVID-19初始症状数量有关。同时，12个月时32.99%的PD患者报告有持续性疲劳。使用抗病毒药物、身体活动减少、焦虑状态和“开”期延迟与12个月时的持续性疲劳有关。在我们的研究中，COVID感染后12个月时临床上持续性疲劳很普遍。这些发现表明，使用抗病毒药物、身体活动减少、焦虑状态和“开”期延迟可能是COVID-19后持续性疲劳的预测因素。
