急性呼吸道合胞病毒感染儿童对呼吸道合胞病毒结构蛋白的抗体反应。
Antibody response to respiratory syncytial virus structural proteins in children with acute respiratory syncytial virus infection.
作者信息
Vainionpää R, Meurman O, Sarkkinen H
出版信息
J Virol. 1985 Mar;53(3):976-9. doi: 10.1128/JVI.53.3.976-979.1985.
Abstract
The purified respiratory syncytial virus (RSV), Randall strain contained 10 polypeptides (72,000 molecular weight [72K], 66K, 48K, 42K, 40K, 36K, 30K, 23K, 18K, and 15K), 8 of which proved to be virus specific, and polypeptides 48K and 23K were glycosylated. In addition, a high-molecular-weight (150K), virus-specific glycopolypeptide was immunoprecipitated from RSV-infected cell lysate. The antibody response in human sera serially collected from children with primary RSV infection was mainly directed against the polypeptides 30K, 48K, and 72K. The immune response against the other viral proteins was also already detectable in the acute-phase sera. These results indicate that the immune response in RSV infection differs significantly from those for other diseases caused by paramyxoviruses.
摘要
纯化的呼吸道合胞病毒（RSV）兰德尔株含有10种多肽（分子量72,000 [72K]、66K、48K、42K、40K、36K、30K、23K、18K和15K），其中8种被证明是病毒特异性的，48K和23K多肽是糖基化的。此外，从RSV感染的细胞裂解物中免疫沉淀出一种高分子量（150K）的病毒特异性糖多肽。从原发性RSV感染儿童中连续采集的人血清中的抗体反应主要针对30K、48K和72K多肽。在急性期血清中也已经可以检测到针对其他病毒蛋白的免疫反应。这些结果表明，RSV感染中的免疫反应与副粘病毒引起的其他疾病的免疫反应有显著差异。
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