Reticulating Crystalline Porous Materials for Asymmetric Heterogeneous Catalysis.

Asymmetric catalysis is essential for addressing the increasing demand for enantiopure compounds. Recent advances in reticular chemistry have demonstrated that metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) possess highly regular porous architectures, exceptional tunability, and the ability to incorporate chiral functionalities through their open channels or cavities. These characteristics make them highly effective and enantioselective catalysts for a wide range of asymmetric transformations. The chiral microenvironments within these frameworks facilitate precise control over reactant orientation and transition states, enhancing both catalytic activity and enantioselectivity, thereby offering significant advantages over traditional systems. This review overviews recent developments in chiral MOFs (CMOFs) and chiral COFs (CCOFs), focusing on their design strategies, and synthetic methods, and highlights the structure-property relationships that connect key structural features to asymmetric catalytic performance. Additionally, the current challenges and future prospects in this field are addressed, highlighting the pivotal role of reticular chemistry in the creation of chiral porous materials. It is anticipated that this review will inspire further research into the application of crystalline porous materials in asymmetric catalysis and promote the rational design of novel chiral heterogeneous catalysts for industrial use.