Wang Xiaoyun, Liu Xueyu, Liu Yi, Long Lixi, Zhang Wei
Department of Emergency Medicine, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, People's Republic of China.
Institute of Disaster Medicine, Sichuan University, Chengdu, People's Republic of China.
BMJ Open. 2024 Dec 31;14(12):e093177. doi: 10.1136/bmjopen-2024-093177.
While multiple studies have shown the safety and efficacy of non-operative management, appendectomy remains the standard treatment for uncomplicated acute appendicitis (UAA). This study presents a protocol for a meta-analysis comparing antibiotic therapy, endoscopic retrograde appendicitis therapy (ERAT) and appendectomy in patients with UAA.
We will conduct a systematic search of several databases, including PubMed, Web of Science, Embase, the China National Knowledge Infrastructure and the Cochrane Library. The search will cover the full range of database records up to September 2024. Eligible studies will include randomised-controlled trials (RCTs) evaluating the efficacy of antibiotic therapy, ERAT and appendectomy for UAA. The primary outcome will be treatment success, while secondary outcomes will include major complications, hospital costs, length of stay and recurrence of appendicitis. Two independent reviewers will select studies, extract data and assess bias risk. A Bayesian approach will be used for the network meta-analysis.
Ethical approval is not required as the study will use data from published RCTs. The findings will be disseminated through publication in peer-reviewed journals.
CRD42024554427.
尽管多项研究已表明非手术治疗的安全性和有效性，但阑尾切除术仍是单纯性急性阑尾炎（UAA）的标准治疗方法。本研究提出了一项荟萃分析方案，比较抗生素治疗、内镜逆行阑尾炎治疗（ERAT）和阑尾切除术在UAA患者中的疗效。
我们将对多个数据库进行系统检索，包括PubMed、科学网、Embase、中国知网和Cochrane图书馆。检索将涵盖截至2024年9月的所有数据库记录。符合条件的研究将包括评估抗生素治疗、ERAT和阑尾切除术治疗UAA疗效的随机对照试验（RCT）。主要结局将是治疗成功，次要结局将包括主要并发症、住院费用、住院时间和阑尾炎复发。两名独立的评审员将选择研究、提取数据并评估偏倚风险。将采用贝叶斯方法进行网络荟萃分析。
由于本研究将使用已发表RCT的数据，因此无需伦理批准。研究结果将通过在同行评审期刊上发表进行传播。
PROSPERO注册号：CRD42024554427。
