Worede Abebaw, Deress Teshiwal, Wondifraw Habtamu, Fetene Getnet, Berie Alemseged
Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Department of Quality Assurance and Laboratory Management, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Front Med (Lausanne). 2024 Dec 17;11:1451036. doi: 10.3389/fmed.2024.1451036. eCollection 2024.
Hyperemesis gravidarum affects about 4.8% of pregnant women. It can lead to electrolyte imbalances and liver function disturbances, which may result in pregnancy complications. Despite its prevalence, data on these abnormalities in the study area is scarce. Therefore, the current study investigated these health concerns among HG-affected pregnant women in this region from June to October 2023.
A comparative cross-sectional study was conducted on 123 study participants. Socio-demographic, clinical, and anthropometric data were collected using structured questionnaires. Blood samples were taken to determine liver function tests and electrolyte levels. Statistical analysis was performed using a one-way ANOVA with a Tuckey test, Kruskal-Wallis with a Mann-Whitney test, and binary logistic regression analysis. A -value of <0.05 with 95% confidence intervals was considered statistically significant.
The results showed that pregnant women with hyperemesis gravidarum had significantly higher levels of AST and ALT and lower levels of Na+ and K+ compared to normal pregnant women and non-pregnant women. The abnormalities observed were elevated AST (48.8%), ALT (46.3%), and decreased Na+ (51.2%) and K+ (41.5%). Hyperemesis gravidarum was associated with both electrolyte imbalances and liver function test abnormalities.
Pregnant women with hyperemesis gravidarum experience electrolyte imbalances and liver function test abnormalities. Given the marked increase in liver enzymes and decrease in electrolyte levels, the authors recommend routine laboratory testing of liver function and electrolyte parameters for pregnant women with hyperemesis gravidarum is recommended.
妊娠剧吐影响约4.8%的孕妇。它可导致电解质失衡和肝功能紊乱，这可能会引发妊娠并发症。尽管其很常见，但研究区域内关于这些异常情况的数据却很稀少。因此，本研究于2023年6月至10月调查了该地区受妊娠剧吐影响的孕妇的这些健康问题。
对123名研究参与者进行了一项比较横断面研究。使用结构化问卷收集社会人口统计学、临床和人体测量数据。采集血样以测定肝功能测试和电解质水平。使用单因素方差分析和Tuckey检验、Kruskal-Wallis检验和Mann-Whitney检验以及二元逻辑回归分析进行统计分析。P值<0.05且置信区间为95%被认为具有统计学意义。
结果显示，与正常孕妇和非孕妇相比，妊娠剧吐孕妇的AST和ALT水平显著更高，而Na+和K+水平更低。观察到的异常情况为AST升高（48.8%）、ALT升高（46.3%）以及Na+降低（51.2%）和K+降低（41.5%）。妊娠剧吐与电解质失衡和肝功能测试异常均相关。
妊娠剧吐孕妇会出现电解质失衡和肝功能测试异常。鉴于肝酶显著升高和电解质水平降低，作者建议对妊娠剧吐孕妇进行肝功能和电解质参数的常规实验室检测。
