[Effect of long-term hypokinesia on the serum lipid spectrum].

The effect of 120-day head-down tilt on the lipid spectrum of blood serum was investigated. By thin-layer and gas liquid chromatography lipids (total lipids, phospholipids, cholesterol and its esters, nonesterified fatty acids, triglycerides) and higher fatty acids were identified. It was found that cholesterolemia increased at the expense of the ester bound fraction, phospholipids decreased drastically, the ratio of phospholipids to total cholesterol decreased, and triglyceridemia diminished. Until bed rest day 70 saturated fatty acids were predominant, with linoleic acid being deficient, and thereafter the relative content of unsaturated fatty acids increased. The above changes in the lipid spectrum can be considered as risk factors with respect to preclinical stages of atherosclerosis.