Liu Yaqing, Zou Shi, Song Shihui, Wan Yingcai, Wu Jianbo, Luo Mingqi, Guo Wei, Liang Ke
Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.
Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China.
Am J Trop Med Hyg. 2024 Dec 31;112(3):677-681. doi: 10.4269/ajtmh.24-0304. Print 2025 Mar 5.
People living with HIV (PLWH) are known to exhibit more severe or prolonged symptoms of mpox (formerly monkeypox). However, the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on PLWH with mpox has not been adequately described. We report a case of mpox in an AIDS patient who had recurrent symptoms due to SARS-CoV-2 infection. The patient presented with a low CD4+ lymphocyte count (CD4 count) without antiretroviral therapy (ART) and suffered from severe mpox. The ART was initiated 17 days after the diagnosis of mpox, and the patient's skin lesions began crusting after 1 week of ART. However, after a SARS-CoV-2 infection, the mpox flared up again. The patient presented with more severe symptoms than those during the initial bout and with rectal involvement. We speculate that SARS-CoV-2 infection might cause a recrudescence of mpox in AIDS patients, which requires further investigation.
已知人类免疫缺陷病毒感染者（PLWH）会出现更严重或持续时间更长的猴痘（原称猴天花）症状。然而，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）对合并猴痘的PLWH的影响尚未得到充分描述。我们报告了一例艾滋病患者的猴痘病例，该患者因SARS-CoV-2感染出现反复症状。患者在未接受抗逆转录病毒治疗（ART）的情况下CD4+淋巴细胞计数较低（CD4计数），并患有严重猴痘。在猴痘诊断17天后开始ART，ART治疗1周后患者的皮肤病变开始结痂。然而，在感染SARS-CoV-2后，猴痘再次发作。患者出现了比初次发作时更严重的症状，且直肠受累。我们推测SARS-CoV-2感染可能导致艾滋病患者猴痘复发，这需要进一步研究。
