自噬受体启发的嵌合体：一种通过自噬降解促进蛋白质聚集体和细胞器清除的新方法。
Autophagy receptor-inspired chimeras: a novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation.
作者信息
Wang Liwen, Liu Huimei, Li Lanfang
机构信息
Institute of Pharmaceutical Pharmacology, School of Pharmacy, University of South China, Hengyang 421001, China.
Hengyang Medical School, University of South China, Hengyang 421001, China.
出版信息
J Zhejiang Univ Sci B. 2024 Sep 25;25(12):1115-1119. doi: 10.1631/jzus.B2300853.
Abstract
Neurodegenerative diseases (NDDs), mainly including Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), and Alzheimer's disease (AD), are sporadic and rare genetic disorders of the central nervous system. A key feature of these conditions is the slow accumulation of misfolded protein deposits in brain neurons, the excessive aggregation of which leads to neurotoxicity and further disorders of the nervous system.
摘要
神经退行性疾病（NDDs），主要包括亨廷顿舞蹈症（HD）、肌萎缩侧索硬化症（ALS）和阿尔茨海默病（AD），是中枢神经系统的散发性罕见遗传疾病。这些病症的一个关键特征是脑神经元中错误折叠的蛋白质沉积物缓慢积累，其过度聚集会导致神经毒性和进一步的神经系统紊乱。
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