Algomizy Hamza, Khan Amjad, Smettei Osama, Elhabiby Mahmoud, Mustafa Ayman Abu, Mohieldein Abdelmarouf
Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah, Saudi Arabia.
Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraidah, Saudi Arabia.
J Res Med Sci. 2024 Oct 24;29:63. doi: 10.4103/jrms.jrms_686_23. eCollection 2024.
Evidence-based screening is crucial to detect myocardial ischemia in high-risk diabetics. We explored the relationship between nitric oxide (NO) levels, lipid profile indices, and atherogenic index of plasma (AIP) in type 2 diabetics with coronary artery disease (CAD) and to determine their potential as prognostic markers.
A case-control study included 50 diabetics with CAD (cases), 30 diabetics without CAD (control 1), and 23 healthy controls (control 2). Biochemical parameters were determined using standard protocols; plasma NO was measured via the Griess reaction.
Cases had the highest levels of NO, fasting blood sugar, glycated hemoglobin (HbA1c), and triglycerides, and the lowest total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels. Cases exhibited the highest TC: HDL-C, LDL-C: HDL-C, and AIP ratios. A significant positive correlation between NO and HbA1c ( = 0.328, = 0.020).
Chronic hyperglycemia could enhance NO overproduction driven by inducible isoform, suggesting a potential role for chronic hyperglycemia in endothelial dysfunction and vascular complications in diabetes.
基于证据的筛查对于检测高危糖尿病患者的心肌缺血至关重要。我们探讨了2型冠心病（CAD）糖尿病患者中一氧化氮（NO）水平、血脂谱指标与血浆致动脉粥样硬化指数（AIP）之间的关系，并确定它们作为预后标志物的潜力。
一项病例对照研究纳入了50例CAD糖尿病患者（病例组）、30例无CAD糖尿病患者（对照组1）和23例健康对照者（对照组2）。使用标准方案测定生化参数；通过格里斯反应测量血浆NO。
病例组的NO、空腹血糖、糖化血红蛋白（HbA1c）和甘油三酯水平最高，总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平最低。病例组的TC:HDL-C、LDL-C:HDL-C和AIP比值最高。NO与HbA1c之间存在显著正相关（=0.328，=0.020）。
慢性高血糖可能会增强由诱导型异构体驱动的NO过量产生，提示慢性高血糖在糖尿病血管内皮功能障碍和血管并发症中可能发挥作用。
