Chkir Baraa, Sivaji Aroon
Urology, Royal Albert Edward Infirmary; Wrightington, Wigan and Leigh NHS Foundation Trust, Wigan, GBR.
Emergency Medicine, Whiston Hospital; Mersey and West Lancashire Teaching Hospitals NHS Trust, Whiston, GBR.
Cureus. 2024 Dec 1;16(12):e74897. doi: 10.7759/cureus.74897. eCollection 2024 Dec.
Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting, and ultimately benign condition characterised by localised lymphadenopathy. The association of KFD with aseptic meningitis is even more uncommon. We report a case of KFD accompanied by aseptic meningitis in a 31-year-old male who initially presented with lethargy, night sweats, axillary lymphadenopathy, and oral ulcers. Initial differential diagnoses included Lyme disease and lymphoma, which were subsequently ruled out. The patient presented again 10 days later with a severe headache. Neurological examination revealed negative Kernig and Brudzinski signs and normal motor power, tone, and reflexes. Lumbar puncture (LP) indicated normal glucose and white cell count. A lymph node biopsy confirmed the diagnosis of Kikuchi's disease with aseptic meningitis. This case underscores the importance of considering KFD in patients presenting with lymphoma-like symptoms.
菊池-藤本病(KFD)是一种罕见的、自限性且最终为良性的疾病,其特征为局限性淋巴结病。KFD与无菌性脑膜炎的关联更为罕见。我们报告一例31岁男性的KFD伴无菌性脑膜炎病例,该患者最初表现为嗜睡、盗汗、腋窝淋巴结病和口腔溃疡。最初的鉴别诊断包括莱姆病和淋巴瘤,随后排除了这些疾病。10天后患者再次就诊,出现严重头痛。神经系统检查显示克尼格征和布鲁津斯基征阴性,运动力量、肌张力和反射正常。腰椎穿刺(LP)显示葡萄糖和白细胞计数正常。淋巴结活检确诊为菊池病伴无菌性脑膜炎。该病例强调了在出现淋巴瘤样症状的患者中考虑KFD的重要性。