Burgos Rafael Agustín, Manosalva Carolina, Alarcón Pablo, Navarro Max, Quiroga John, Morán Gabriel, Gallastegui Jan, Brauchi Sebastián, Carretta María Daniella
Laboratory of Inflammation Pharmacology and Immunometabolism, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile.
Institute of Pharmacy, Faculty of Sciences, Universidad Austral de Chile, Valdivia, Chile.
Front Vet Sci. 2024 Dec 18;11:1509399. doi: 10.3389/fvets.2024.1509399. eCollection 2024.
D-lactic acidosis is associated with fermentative disturbances and is often marked by elevated levels of D-lactic acid in the blood, ruminal fluid, and synovial fluid in cattle. D-lactic acidosis is linked to various inflammatory manifestations, and although the causative factors have been extensively explored, the exact pathogenesis of the associated inflammation remains elusive. Notably, less attention has been given to D-lactate, a stereoisomer found in the plasma of affected animals, which may lead to D-lactic acidosis. This review aims to highlight the evidence suggesting that D-lactate participates in the modulation of inflammatory processes and explore its potential effects on synoviocytes, polymorphonuclear neutrophils, macrophages, and T-cells. This comprehensive examination of D-lactate's involvement in the inflammatory response process provides timely insights into the pathophysiological aspects of ruminal acidosis in cattle.
D-乳酸酸中毒与发酵紊乱有关，常表现为牛的血液、瘤胃液和滑液中D-乳酸水平升高。D-乳酸酸中毒与多种炎症表现相关，尽管对其致病因素已进行了广泛研究，但相关炎症的确切发病机制仍不清楚。值得注意的是，在受影响动物血浆中发现的立体异构体D-乳酸受到的关注较少，而它可能导致D-乳酸酸中毒。本综述旨在强调表明D-乳酸参与炎症过程调节的证据，并探讨其对滑膜细胞、多形核中性粒细胞、巨噬细胞和T细胞的潜在影响。对D-乳酸参与炎症反应过程的全面研究为深入了解牛瘤胃酸中毒的病理生理学方面提供了及时的见解。
