• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Overlapping DNA methylation changes in enhancers in clonal cytopenia of undetermined significance and myelodysplastic neoplasm patients with , , or mutations.

作者信息

Kaastrup Katja, Tulstrup Morten, Hansen Jakob W, Schöllkopf Claudia, Raaschou-Jensen Klas, Ørskov Andreas D, Porse Bo, Jones Peter A, Weischenfeldt Joachim, Gillberg Linn, Grønbæk Kirsten

机构信息

The Epi-/Genome lab, Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen.

The Epi-/Genome lab, Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen.

出版信息

Haematologica. 2025 May 1;110(5):1164-1169. doi: 10.3324/haematol.2024.285466. Epub 2025 Jan 2.

DOI:10.3324/haematol.2024.285466
PMID:39744828
原文链接:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12050920/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ce/12050920/61e4fecee12a/1101164.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ce/12050920/8f3a57cc574d/1101164.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ce/12050920/6c59fef0ab72/1101164.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ce/12050920/61e4fecee12a/1101164.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ce/12050920/8f3a57cc574d/1101164.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ce/12050920/6c59fef0ab72/1101164.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8ce/12050920/61e4fecee12a/1101164.fig3.jpg

相似文献

1
Overlapping DNA methylation changes in enhancers in clonal cytopenia of undetermined significance and myelodysplastic neoplasm patients with , , or mutations.意义未明的克隆性血细胞减少症和伴有 、 或 突变的骨髓增生异常肿瘤患者增强子中重叠的DNA甲基化变化。
Haematologica. 2025 May 1;110(5):1164-1169. doi: 10.3324/haematol.2024.285466. Epub 2025 Jan 2.
2
Clonal Hematopoiesis and Bone Marrow Infiltration in Patients With Follicular Helper T-Cell Lymphoma of Angioimmunoblastic Type.克隆性造血与骨髓浸润在生发中心 B 细胞型滤泡辅助性 T 细胞淋巴瘤患者中的临床意义
Mod Pathol. 2024 Jul;37(7):100519. doi: 10.1016/j.modpat.2024.100519. Epub 2024 May 21.
3
Clonal cytopenia of undetermined significance (CCUS) with dysplasia is enriched for MDS-type molecular findings compared to CCUS without dysplasia.意义未明的克隆性血细胞减少伴发育异常（CCUS-D）与不伴发育异常的 CCUS 相比，富集了 MDS 型分子发现。
Eur J Haematol. 2021 Apr;106(4):500-507. doi: 10.1111/ejh.13574. Epub 2021 Jan 15.
4
Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: a report from the Children's Oncology Group.在儿科急性髓系白血病（AML）中，甲基化相关基因 DNMT3A 和 IDH2 的白血病突变是罕见事件：来自儿童肿瘤协作组的报告。
Pediatr Blood Cancer. 2011 Aug;57(2):204-9. doi: 10.1002/pbc.23179. Epub 2011 Apr 18.
5
Predicting cytopenias, progression, and survival in patients with clonal cytopenia of undetermined significance: a prospective cohort study.预测具有意义未明的克隆性血细胞减少症患者的细胞减少症、进展和生存情况：一项前瞻性队列研究。
Lancet Haematol. 2024 Jan;11(1):e51-e61. doi: 10.1016/S2352-3026(23)00340-X.
6
Comparison of SF3B1/DNMT3A Comutations With DNMT3A or SF3B1 Mutation Alone in Myelodysplastic Syndrome and Clonal Cytopenia of Undetermined Significance.SF3B1/DNMT3A 基因突变与单独 DNMT3A 或 SF3B1 基因突变在骨髓增生异常综合征和意义未明的克隆性血细胞减少症中的比较。
Am J Clin Pathol. 2020 Jun 8;154(1):48-56. doi: 10.1093/ajcp/aqaa016.
7
Clonal Cytopenia of Undetermined Significance in a Patient with Congenital Wilms' Tumor 1 and Acquired DNMT3A Gene Mutations.先天性 Wilms 瘤 1 合并获得性 DNMT3A 基因突变患者的意义未明克隆性细胞减少症。
Intern Med. 2021 Dec 1;60(23):3785-3788. doi: 10.2169/internalmedicine.7571-21. Epub 2021 May 29.
8
Inflammation in myelodysplastic syndrome pathogenesis.骨髓增生异常综合征发病机制中的炎症
Semin Hematol. 2024 Dec;61(6):385-396. doi: 10.1053/j.seminhematol.2024.09.005. Epub 2024 Sep 21.
9
How I investigate Clonal cytogenetic abnormalities of undetermined significance.如何检测意义未明的克隆细胞遗传学异常
Int J Lab Hematol. 2018 Aug;40(4):385-391. doi: 10.1111/ijlh.12826. Epub 2018 Apr 6.
10
TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis.TET2 突变与正常和恶性造血中关键调节增强子的高甲基化有关。
Nat Commun. 2021 Oct 18;12(1):6061. doi: 10.1038/s41467-021-26093-2.

本文引用的文献

1
Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease.克隆性造血不定潜能、DNA 甲基化与冠状动脉疾病风险。
Nat Commun. 2022 Sep 12;13(1):5350. doi: 10.1038/s41467-022-33093-3.
2
The longitudinal dynamics and natural history of clonal haematopoiesis.克隆性造血的纵向动力学和自然史。
Nature. 2022 Jun;606(7913):335-342. doi: 10.1038/s41586-022-04785-z. Epub 2022 Jun 1.
3
Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells.在 IDH 突变型 AML 细胞中，增强子处 DNA 甲基化动态的局灶性破坏。
Leukemia. 2022 Apr;36(4):935-945. doi: 10.1038/s41375-021-01476-y. Epub 2021 Dec 6.
4
TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis.TET2 突变与正常和恶性造血中关键调节增强子的高甲基化有关。
Nat Commun. 2021 Oct 18;12(1):6061. doi: 10.1038/s41467-021-26093-2.
5
A genome-scale map of DNA methylation turnover identifies site-specific dependencies of DNMT and TET activity.全基因组 DNA 甲基化周转率图谱鉴定出 DNMT 和 TET 活性的位点特异性依赖性。
Nat Commun. 2020 May 29;11(1):2680. doi: 10.1038/s41467-020-16354-x.
6
ChAMP: updated methylation analysis pipeline for Illumina BeadChips.ChAMP：Illumina BeadChips 甲基化分析更新流程。
Bioinformatics. 2017 Dec 15;33(24):3982-3984. doi: 10.1093/bioinformatics/btx513.
7
Mutations in idiopathic cytopenia of undetermined significance assist diagnostics and correlate to dysplastic changes.不明原因血细胞减少症的基因突变有助于诊断，并与发育不良变化相关。
Am J Hematol. 2016 Dec;91(12):1234-1238. doi: 10.1002/ajh.24554. Epub 2016 Nov 8.
8
Integrative analysis of 111 reference human epigenomes.111 个人类参考基因组的综合分析。
Nature. 2015 Feb 19;518(7539):317-30. doi: 10.1038/nature14248.
9
limma powers differential expression analyses for RNA-sequencing and microarray studies.limma为RNA测序和微阵列研究提供差异表达分析的动力。
Nucleic Acids Res. 2015 Apr 20;43(7):e47. doi: 10.1093/nar/gkv007. Epub 2015 Jan 20.
10
Functional normalization of 450k methylation array data improves replication in large cancer studies.450k甲基化阵列数据的功能标准化可提高大型癌症研究中的重复性。
Genome Biol. 2014 Dec 3;15(12):503. doi: 10.1186/s13059-014-0503-2.