Zou Yanqiu, Jin Huaizhou, Ma Qifei, Zheng Zhenrong, Weng Shukun, Kolataj Karol, Acuna Guillermo, Bald Ilko, Garoli Denis
College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China.
Key Laboratory of Quantum Precision Measurement, College of Physics, Zhejiang University of Technology, Hangzhou, China.
Nanoscale. 2025 Feb 13;17(7):3656-3670. doi: 10.1039/d4nr04239e.
Dynamic surface-enhanced Raman spectroscopy (SERS) is nowadays one of the most interesting applications of SERS, in particular for single molecule studies. In fact, it enables the study of real-time processes at the molecular level. This review summarizes the latest developments in dynamic SERS techniques and their applications, focusing on new instrumentation, data analysis methods, temporal resolution and sensitivity improvements, and novel substrates. We highlight the progress and applications of single-molecule dynamic SERS in monitoring chemical reactions, catalysis, biomolecular interactions, conformational dynamics, and real-time sensing and detection. We aim to provide a comprehensive review on its advancements, applications as well as its current challenges and development frontiers.
动态表面增强拉曼光谱（SERS）如今是SERS最有趣的应用之一，特别是在单分子研究方面。事实上，它能够在分子水平上研究实时过程。本综述总结了动态SERS技术及其应用的最新进展，重点关注新仪器、数据分析方法、时间分辨率和灵敏度的提高以及新型基底。我们强调了单分子动态SERS在监测化学反应、催化、生物分子相互作用、构象动力学以及实时传感和检测方面的进展和应用。我们旨在对其进展、应用以及当前的挑战和发展前沿进行全面综述。
