Yavuz Emre, Sakir Menekse, Onses M Serdar, Salem Samaa, Yilmaz Erkan
Erzincan Binali Yildirim University, Cayirli Vocational School, Department of Medical Services and Technicians, 24503, Erzincan, Turkey.
ERNAM-Erciyes University Nanotechnology Application and Research Center, Kayseri, 38039, Turkey.
Talanta. 2024 Nov 1;279:126640. doi: 10.1016/j.talanta.2024.126640. Epub 2024 Jul 31.
Surface Enhanced Raman Spectroscopy (SERS) technique is an effective analytical technique in which fingerprint information about analytes can be obtained, can provide detection limit performance at the single molecule level, and analyzes are performed in a single step without any intermediate steps. SERS technique offers additional benefits rather than other analytical techniques including high selectivity, ultrasensitive detection, uncomplicated protocols, in situ sampling, on-set capability and cost-effectiveness. As a result of the combination of developments in materials and nanotechnology science with the SERS analysis technique, this technique strengthens its use advantage day by day. The most important factor that limited the use of this technique was the fact that the solution containing the desired analyte(s) was dropped onto the SERS substrate and the same substrate could not be reused in subsequent analyses. To solve this problem, scientists have focused on developing reusable SERS substrates in recent years. In these studies, scientists basically used three SERS substrate cleaning applications (1) washing the SERS substrate with a suitable solvent that can elute the analyte from SERS surface after analysis, (2) cleaning the SERS substrate with catalytic degradation of analytes after analysis by modifying them with catalytic active materials and (3) Applying plasma cleaning procedure to SERS substrate after analysis and (4) applying adsorption and desorption procedure prior to SERS analysis. Herein, the aim of this review article is to evaluate the reusable SERS substrates-based methods based on their level of development and their potential to recycle. This review offers a coherent discussion on a wide range of sensing schemes employed in fabricating the SERS substrates. We utilized a critical approach in which elaborative examples were selected to highlight key shortcomings of various experimental configurations. In the same vein, there is a discussion of the advantages and limitations concerning the key instrumental advances and the expansion of the recent methods developed in this area.
表面增强拉曼光谱（SERS）技术是一种有效的分析技术，可获取有关分析物的指纹信息，能在单分子水平提供检测限性能，且分析一步完成无需任何中间步骤。SERS技术比其他分析技术具有更多优势，包括高选择性、超灵敏检测、操作流程简单、原位采样、即时检测能力和成本效益。由于材料科学和纳米技术的发展与SERS分析技术相结合，该技术的使用优势日益增强。限制该技术应用的最重要因素是，含有所需分析物的溶液滴加到SERS基底上后，同一基底在后续分析中无法重复使用。为解决这个问题，近年来科学家们致力于开发可重复使用的SERS基底。在这些研究中，科学家们主要采用了三种SERS基底清洗方法：（1）用合适的溶剂清洗SERS基底，该溶剂在分析后可从SERS表面洗脱分析物；（2）在分析后通过用催化活性材料对分析物进行改性，以催化降解的方式清洗SERS基底；（3）在分析后对SERS基底应用等离子体清洗程序；（4）在SERS分析之前应用吸附和解吸程序。在此，这篇综述文章的目的是根据基于可重复使用SERS基底的方法的发展水平及其回收潜力对其进行评估。这篇综述对制造SERS基底所采用的各种传感方案进行了连贯的讨论。我们采用了一种批判性方法，选择详细的例子来突出各种实验配置的关键缺点。同样，也讨论了有关关键仪器进展的优点和局限性以及该领域最近开发的方法的扩展。
